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Inhibin B response to testicular toxicants hexachlorophene, ethane dimethane sulfonate, di-(n-butyl)-phthalate, nitrofurazone, DL-ethionine, 17-alpha ethinylestradiol, 2,5-hexanedione, or carbendazim following short-term dosing in male rats.
Birth Defects Res B Dev Reprod Toxicol
February 2013
Merck Research Laboratories, West Point, PA 19486, USA.
Background: Inhibin B is a heterodimer glycoprotein that downregulates follicle-stimulating hormone and is produced predominantly by Sertoli cells. The potential correlation between changes in plasma Inhibin B and Sertoli cell toxicity was evaluated in male rats administered testicular toxicants in eight studies. Inhibin B fluctuations over 24 hr were also measured.
View Article and Find Full Text PDFAryl hydrocarbon receptor regulates pancreatic IL-22 production and protects mice from acute pancreatitis.
Gastroenterology
December 2012
Stanford University School of Medicine, Department of Medicine, Division of Gastroenterology and Hepatology, Stanford, California, USA.
Background & Aims: The type of immune response during development of acute pancreatitis (AP) determines disease severity. Pancreatic epithelial cells express the interleukin (IL)-22 receptor A1 (IL-22RA1). The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor that regulates expression of IL-22.
View Article and Find Full Text PDFSulindac prevents carcinogen-induced intrahepatic cholangiocarcinoma formation in vivo.
J Surg Res
November 2009
Department of Surgery, Indiana University School of Medicine, Indianapolis, USA.
Background: Intrahepatic cholangiocarcinoma (ICC) incidence and mortality are increasing in the United States and worldwide. ICC etiologies involve chronic inflammation. We hypothesize that the nonsteroidal anti-inflammatory agent sulindac may prevent ICC by targeting cyclooxygenase-1 and -2 (COX-1, -2) as well as COX-independent pathways.
View Article and Find Full Text PDFTotal glutathione and glutathione reductase in bovine erythrocytes and liver biopsy.
J Vet Med Sci
August 2008
Veterinary Teaching Hospital, Faculty of Agriculture, Iwate University, Morioka, Japan.
The goal of the present study was to measure the total glutathione level and glutathione reductase activity in bovine erythrocytes and liver biopsy. Five cows were injected intraperitoneally with DL-ethionine (12.5 mg/kg B.
View Article and Find Full Text PDFSuperoxide dismutase activity as a measure of hepatic oxidative stress in cattle following ethionine administration.
Vet J
November 2009
Veterinary Teaching Hospital, Faculty of Agriculture, Iwate University, 3-18-8 Ueda, Morioka 0208550, Japan.
The goal of this study was to assess if oxidative stress, as measured by alterations in the concentrations of antioxidant enzymes in the liver and erythrocytes of cattle, could be induced following dl-ethionine administration. Whole blood, serum and liver biopsy samples were collected 0, 4, 7 and 10 days after intra-peritoneal ethionine administration to five cows. The activities of the antioxidant enzymes copper zinc superoxide dismutase (Cu, Zn SOD) and catalase were assessed in the liver biopsies which were also examined histopathologically.
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