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Comparisons of neurodegenerative disease biomarkers across different biological fluids from patients with Huntington's disease.
J Neurol
January 2025
Department of Neurobiology and Behavior, University of California Irvine, Irvine, CA, USA.
Fluid biomarkers play important roles in many aspects of neurodegenerative diseases, such as Huntington's disease (HD). However, a main question relates to how well levels of biomarkers measured in CSF are correlated with those measured in peripheral fluids, such as blood or saliva. In this study, we quantified levels of four neurodegenerative disease-related proteins, neurofilament light (NfL), total tau (t-tau), glial fibrillary acidic protein (GFAP) and YKL-40 in matched CSF, plasma and saliva samples from Huntingtin (HTT) gene-positive individuals (n = 21) using electrochemiluminescence assays.
View Article and Find Full Text PDFEndosymbionts as hidden players in tripartite pathosystem of interactions and potential candidates for sustainable viral disease management.
Crit Rev Biotechnol
January 2025
Key Laboratory of Agricultural Microbiology, College of Agriculture, Guizhou University, Guiyang, P.R. China.
The convoluted relationships between plants, viruses, and arthropod vectors housing bacterial endosymbionts are pivotal in the spread of harmful plant viral diseases. Endosymbionts play key roles in: manipulating host responses, influencing insect resistance to pesticides, shaping insect evolution, and bolstering virus acquisition, retention, and transmission. This interplay presents an innovative approach for developing sustainable strategies to manage plant diseases.
View Article and Find Full Text PDFRisk of bias assessment tools often addressed items not related to risk of bias and used numerical scores.
J Clin Epidemiol
January 2025
Division of Nephrology and Hypertension, Department of Internal Medicine, University of Kansas Medical Centre, 3901 Rainbow Blvd, MS3002, Kansas City, KS, USA. Electronic address:
Objective: We aimed to determine whether the existing risk of bias assessment tools addressed constructs other than risk of bias or internal validity, and whether they used numerical scores to express quality, which is discouraged and may be a misleading approach.
Methods: We searched Ovid MEDLINE and Embase to identify quality appraisal tools across all disciplines in human health research. Tools designed specifically to evaluate reporting quality were excluded.
Introduction: Broca's Aphasia (BA) is a language disorder that causes grammatical errors in the language production skills of patients. Contemporary studies revealed the fact that BA patients also have difficulty in analyzing the meaning of phrases and sentences and comprehending the real meaning of the discourse produced by the speaker. The purpose of this study is to investigate possible effect of syntactic movement by changing the word positions in the sentence with morphological markers in order to produce clauses without changing the meaning on the phrasal comprehension skills of Turkish speaking patients with BA.
View Article and Find Full Text PDFUnICLAM: Contrastive representation learning with adversarial masking for unified and interpretable Medical Vision Question Answering.
Med Image Anal
January 2025
Sixth Medical Center of Chinese PLA General Hospital, Beijing, 100037, China. Electronic address:
Medical Visual Question Answering aims to assist doctors in decision-making when answering clinical questions regarding radiology images. Nevertheless, current models learn cross-modal representations through residing vision and text encoders in dual separate spaces, which inevitably leads to indirect semantic alignment. In this paper, we propose UnICLAM, a Unified and Interpretable Medical-VQA model through Contrastive Representation Learning with Adversarial Masking.
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