Objective: To assess the value of four T(1)-weighted (T(1)W) gradient-recalled-echo (GRE) sequences in MnDPDP-enhanced magnetic resonance imaging (MRI) for diagnosing primary hepatocellular carcinoma (HCC).
Methods: T(1)W images of fast low-angle shot (FLASH), fat-suppressed (FS) FLASH, in-phase and opposed-phase (IP/OP) FLASH were obtained from 13 HCC patients before and 30 min after the patients were given 5 micromol/kg.b.w. MnDPDP. The delayed (24 h) images were also obtained with the same sequences in addition to the T(2)W turbo spin-echo (TSE) sequence performed before MnDPDP administration. The signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) of the liver parenchyma and the tumor foci were calculated for each sequence.
Results: No statistical differences were found in SNR and CNR between the images obtained with the four T(1)W sequences (P > 0.05). The fatty degeneration of HCC could be detected by OP imaging, but not by T(1)W FLASH or IP T(1)W imaging.
Conclusion: IP and OP FLASH produces better and easier performance in characterizing the fatty degeneration of HCC, and are recommended for MnDPDP-enhanced MRI of HCC.
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