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[The patterns in the functioning of the hypothalamo-hypophyseal-adrenal cortex system].
Usp Fiziol Nauk
June 1993
Main principles of functioning of the hypothalamus-hypophysis-adrenal cortex system (HHACS) in conditions of stress activation and rhythmic excitation and inhibition are characterized. Interrelations between input signals, disturbing the HHACS, and output parameters of its activity, are described. The role of central and peripheral parts of HHACS in the realization of the principles of its functioning is analyzed.
View Article and Find Full Text PDFIn patients with thyrotoxicosis combined with primary affection of the central nervous system (CNS)-encephalitis, diencephalitis-there was revealed, like in common thyrotoxicosis, an increased production by the adrenal cortex of hydrocortisone, its intensified transformation and inactivation, reduced production of 17-ketosteroid chiefly due to the fall of dehydroepiandrosterone content, an increased urinary excretion of adrenaline and a decreased-of noradrenaline. The use of functional test with the ACTH administration demonstrated organic affection of the CNS to sharply aggravate the weakening and even the exhaustion of the functional reserves of the glomerular and the reticular zones of the adrenal cortex developing during thyrotoxicosis, and also the reserve possibilities of the sympathico-adrenal system. Direction of the changes in the 24-hour excretion of 17-OCS and corticosteriods was the same in the majority of cases.
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