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ANTI-THROMBOTIC STRATEGY FOR THE MANAGEMENT OF NONOCCLUSIVE THROMBUS WITH ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION IN YOUNG PATIENTS - ANTARTICA STUDY.
Indian Heart J
December 2024
Apollo Institute of Medical Sciences and Research, Jubilee Hills, Film Nagar, Hyderabad, Telangana, 500090.
Introduction: Various cardiovascular thrombo-embolic clinical entities use combined ATS for prevention and treatment. After PCI, AF patients are typically prescribed DOAC, DAPT/SAPT, as component of ATS to minimize stroke risk and treat pulmonary embolism and venous thromboembolism. Some small observational studies have shown that a combined ATS can clear small thrombi in LV dysfunction and/or apical aneurysms.
View Article and Find Full Text PDFEfficacy and Safety of Tranexamic Acid in Traumatic Brain Injury: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Cureus
November 2024
Department of Psychiatry, Palmer Community Hospital, South Tyneside, GBR.
Article Synopsis
- Traumatic brain injury (TBI) is a serious health issue worldwide, leading to high rates of death and long-term disability, prompting exploration into treatments like tranexamic acid (TXA) for potential benefits.
- This systematic review analyzed data from 12 randomized controlled trials (RCTs) with nearly 37,500 patients, focusing on TXA's effects on overall mortality and complications like DVT and stroke in TBI patients.
- Results showed that TXA significantly reduced total mortality compared to placebo without increasing risks for thromboembolic events, and there were no significant differences in the need for neurosurgery or other major complications.
The volume-outcome relation for pulmonary endarterectomy in chronic thrombo-embolic pulmonary hypertension.
Eur Respir J
November 2024
Department of Cardiac Surgery, University Hospitals Leuven, Leuven, Belgium.
Background: We conducted a volume-outcome (V-O) meta-analysis of PEA procedures for chronic thromboembolic pulmonary hypertension (CTEPH), to objectively determine the minimum required annual case load that can define a high-volume centre.
Methods: Three electronic databases were systematically queried until May 1st, 2024. Centres were divided in volume tertiles (Ts).
Ability of Activated Clotting Time Measurements to Monitor Unfractionated Heparin Activity During NonCardiac Arterial Procedures.
Ann Vasc Surg
January 2025
Department of Vascular Surgery, Amsterdam UMC, Location VUmc, Amsterdam, The Netherlands; Department of Vascular Surgery, Dijklander Ziekenhuis, Hoorn, The Netherlands; Amsterdam Cardiovascular Sciences, Microcirculation, Amsterdam, The Netherlands. Electronic address:
Background: Activated clotting time (ACT) measurements are frequently used to monitor unfractionated heparin activity during noncardiac arterial procedures (NCAP). Accuracy of ACT-guided heparinization is mandatory to prevent heparin under and overdosing, thereby minimizing thrombo-embolic complications (TECs) and bleeding risk. The main objective of this study was to investigate accuracy of ACT to monitor heparin activity during NCAP using the Hemostasis Management System Plus (HMS) with high-range (HR) cartridges.
View Article and Find Full Text PDFClinical Outcomes of 5000 IU Heparin Versus Activated Clotting Time-Guided Heparinization During Noncardiac Arterial Procedures: A Propensity Score Matched Analysis.
J Endovasc Ther
September 2024
Department of Vascular Surgery, Amsterdam University Medical Center, Vrije Universiteit, Amsterdam, The Netherlands.
Purpose: Previous studies have shown that activated clotting time (ACT)-guided heparinization leads to better anticoagulation levels during noncardiac arterial procedures (NCAP) than a standardized bolus of 5000 IU. Better anticoagulation should potentially result in lower incidence of thrombo-embolic complications (TEC). Comparative investigations on clinical outcomes of these heparinization strategies are scarce.
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