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Exploring In Vivo Human Brain Metabolism at 10.5 T: Initial Insights from MR Spectroscopic Imaging.
Neuroimage
January 2025
Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, USA.
Introduction: Ultra-high-field magnetic resonance (MR) systems (7 T and 9.4 T) offer the ability to probe human brain metabolism with enhanced precision. Here, we present the preliminary findings from 3D MR spectroscopic imaging (MRSI) of the human brain conducted with the world's first 10.
View Article and Find Full Text PDFA single-center, single-arm, prospective, open-label, and comparative trial to evaluate the safety and tolerability profile of a 90-day oral L-arginine hydrochloride intervention for patients with amyotrophic lateral sclerosis.
Sci Rep
January 2025
Department of Clinical Neuroscience and Therapeutics, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, Hiroshima, 734-8551, Japan.
Weight loss, a key indicator of malnutrition in amyotrophic lateral sclerosis (ALS) patients, negatively impacts patient prognosis. However, effective nutritional interventions have not been adequately established. Research in ALS model mice has shown that L-arginine can prolong survival; however, no human intervention studies have been conducted.
View Article and Find Full Text PDFMyotonia Congenita in Australian Merino Sheep with a Missense Variant in .
Animals (Basel)
December 2024
Sydney School of Veterinary Science, The University of Sydney, Camden, NSW 2570, Australia.
Myotonia congenita is a hereditary, non-dystrophic skeletal muscle disorder associated with muscle stiffness due to delayed muscle relaxation after contraction. We review myotonia congenita in domesticated animals and humans and investigated suspected myotonia congenita in a flock of Merino sheep in Australia. In 2020, a property in New South Wales reported a four-year history of lambs that would fall on disturbance before rapidly recovering, with 13 affected sheep identified in 2020.
View Article and Find Full Text PDFClinicopathological biomarker patterns, venom detection and venom proteomics in canine Vipera berus envenomation.
Top Companion Anim Med
December 2024
Department of Preclinical Sciences and Pathology, Faculty of Veterinary Medicine, Norwegian University of Life Sciences, Ås, Norway.
Vipera berus (V. berus) bites are associated with high morbidity, including kidney injury, in dogs. Although antivenom is often used and perceived effective to treat this type of snakebite, it is costly and associated with adverse events and specific diagnostics for this type of snakebite are lacking.
View Article and Find Full Text PDFSupplementing With Which Form of Creatine (Hydrochloride or Monohydrate) Alongside Resistance Training Can Have More Impacts on Anabolic/Catabolic Hormones, Strength and Body Composition?
Physiol Res
November 2024
Department of Exercise Physiology, Faculty of Sport Sciences, University of Guilan, Rasht, Iran.
Article Synopsis
- - The study aimed to assess how resistance training (RT) combined with either creatine-hydrochloride (Cr-HCl) or creatine monohydrate (CrM) affects hormones, strength, and body composition in young adults aged 18-25.
- - Forty participants were split into four groups: those taking Cr-HCl, CrM with a loading phase, CrM without loading, and a placebo group, all undergoing an eight-week RT program.
- - Results demonstrated that those on creatine supplements showed significant improvements in strength, muscle mass, and favorable hormone changes compared to the placebo group, with no notable advantage of Cr-HCl over CrM.
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