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Unlocking the power of empagliflozin: Rescuing inflammation in hyperglycaemia- exposed human cardiomyocytes through comprehensive multi-level analysis.
Eur J Heart Fail
January 2025
Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy.
Aims: Hyperglycaemic conditions increase cardiac stress, a common phenomenon associated with inflammation, aging, and metabolic imbalance. Sodium-glucose cotransporter 2 inhibitors, a class of anti-diabetic drugs, showed to improve cardiovascular functions although their mechanism of action has not yet been fully established. This study investigated the effects of empagliflozin on cardiomyocytes following high glucose exposure, specifically focusing on inflammatory and metabolic responses.
View Article and Find Full Text PDFThe Anti-hyperglycemic and Anti-hyperlipidemic Effects of Trigonella foenum-graecum L. Seeds on Fructose-induced Diabetic Wistar Rats.
Plant Foods Hum Nutr
December 2024
Laboratory of Biology and Health, Faculty of Sciences, Ibn Tofail University, Kenitra, Morocco.
Trigonella foenum-graecum L. (fenugreek) seeds are widely used in the preparation of various meals and in traditional health care to treat various disorders and diseases, especially Diabetes mellitus. This study was conducted to investigate the antihyperglycemic and antihyperlipidemic effects of the fenugreek seed extract on fructose-induced diabetic wistar rats.
View Article and Find Full Text PDFHybrid closed-loop systems for managing blood glucose levels in type 1 diabetes: a systematic review and economic modelling.
Health Technol Assess
December 2024
Warwick Evidence, Division of Health Sciences, Warwick Medical School, University of Warwick, Coventry, UK.
Background: Hybrid closed-loop systems are a new class of technology to manage type 1 diabetes mellitus. The system includes a combination of real-time continuous glucose monitoring from a continuous glucose monitoring device and a control algorithm to direct insulin delivery through an insulin pump. Evidence suggests that such technologies have the potential to improve the lives of people with type 1 diabetes mellitus and their families.
View Article and Find Full Text PDFChemical composition and pharmacological aspects of Malaysian stingless bee propolis: An up‑to‑date systematic review.
Biomed Rep
January 2025
Faculty of Applied Sciences, Universiti Teknologi MARA, 26400 Bandar Tun Abdul Razak Jengka, Pahang, Malaysia.
Propolis is a sticky substance produced by stingless bees for construction and defence of their hive. It has notable anti-inflammatory, antioxidant, antibacterial, antifungal, anti-hyperglycemic, and wound healing effects. The present review summarised and examined the phytochemical properties, mode of action and current research prospects of Malaysian propolis.
View Article and Find Full Text PDFProposed mechanisms of action participating in the hypoglycemic effect of the traditionally used Lotsy and junceic acid, its main compound.
Front Pharmacol
October 2024
Laboratorio de Etnofarmacología, Facultad de Ciencias, Universidad Nacional Autónoma de México, Ciudad Universitaria, Coyoacán, Mexico.
Article Synopsis
- Lotsy, a traditional medicine used by the Cakchiquels of Guatemala for type 2 diabetes, has shown hypoglycemic effects, primarily attributed to its main compound, junceic acid, which had not been previously reported for such activity.
- The study revealed that both Lotsy extract and junceic acid reduce blood glucose levels in rats by inhibiting key enzymes involved in glucose production, highlighting junceic acid's stronger effect compared to the known chlorogenic acid.
- While both compounds decreased insulin levels in various metabolic states, they did not enhance insulin's effectiveness; instead, their insulin-sensitizing effect appears to operate through the activation of the AMP-activated protein kinase
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