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Stochasticity in dietary restriction-mediated lifespan outcomes in Drosophila.
Geroscience
January 2025
Department of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.
Dietary restriction (DR) is widely considered to be one of the most potent approaches to extend healthy lifespan across various species, yet it has become increasingly apparent that DR-mediated longevity is influenced by biological and non-biological factors. We propose that current priorities in the field should include understanding the relative contributions of these factors to elucidate the mechanisms underlying the beneficial effects of DR. Our work conducted in two laboratories represents an attempt to unify DR protocols in Drosophila and to investigate the stochastic effects of DR.
View Article and Find Full Text PDFSelf-perceived knowledge, influencing factors and proposed educational interventions for diagnostic stewardship in the microbiology laboratory: The experience of Irish paediatric doctors.
Ir J Med Sci
January 2025
Department of Clinical Microbiology, Children's Health Ireland at Temple Street Children's University Hospital, Dublin 1, Ireland.
Background: Lab users should display an understanding of microbiology tests and avoid inappropriate requests which may yield negative clinical consequences. Our research addressed diagnostic stewardship education and the perspectives of paediatric hospital doctors on their (1) self-perceived knowledge, (2) motivators for test ordering, (3) proposed educational interventions and (4) preferred teaching modalities.
Methods: An anonymous, mixed-methods, 34-item online questionnaire was distributed to paediatric doctors across three Irish hospital sites from March to May 2023.
Effect of Seasonal Variation on the Cuticular Chemical Composition of Atta laevigata (Smith 1858) (Hymenoptera: Formicidae).
J Chem Ecol
January 2025
Laboratório de Ecologia Comportamental, Centro de Estudos em Recursos Naturais, Universidade Estadual de Mato Grosso do Sul, Dourados, MS, Brazil.
Cuticular hydrocarbons (CHCs) constitute an important class of chemical compounds present in the cuticular layer of insects, where their main functions are to prevent desiccation of the cuticle and as signals for intraspecific recognition. Studies concerning CHCs have shown a phenotypic flexibility of their composition, depending on environmental factors. However, the way that each of these factors influences this variation remains little explored.
View Article and Find Full Text PDFExploring neuroanatomy and neuropsychology in digital financial decision-making: betrayal aversion and risk behavior.
Brain Imaging Behav
January 2025
Faculty of Economics and Business, University of Granada, Campus Universitario de Cartuja, Granada, CP, 18071, Spain.
Detecting the factors associated with financial decision-making is an unresolved challenge when trying to predict digital financial behavior. This paper reports experimental results on both neuropsychological and neuronal correlates of risk-taking and betrayal aversion among 121 healthy participants (X=21.7; SD = 2.
View Article and Find Full Text PDFUpregulation of the MAP2K4 gene triggers endothelial-mesenchymal transition in COVID-19.
Mol Biol Rep
January 2025
Department of Molecular Biology and Genetics, Faculty of Art and Science, Tokat Gaziosmanpasa University, Tokat, 60200, Türkiye.
Background: SARS-CoV-2 infection is marked by an excessive inflammatory response, leading to elevated production of pro-inflammatory cytokines through activation of intracellular pathways like mitogen-activated protein kinase (MAPK). Viruses can use the MAPK signaling pathway to their advantage, but the relationship of this pathway to the severe SARS-CoV-2 period has not been fully elucidated. MAP2K4 is involved in the MAPK signaling pathway and affects cellular processes such as cell-cell junction, cell proliferation, differentiation and apoptosis.
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