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Glucocorticoid Receptor Gene (NR3C1) Methylation Childhood Maltreatment Multilevel Reward Responsiveness and Depressive and Anxiety Symptoms: A Neuroimaging Epigenetic Study.
Neuroimage
January 2025
School of Nursing and Rehabilitation, Cheeloo College of Medicine, Shandong University, Jinan, China. Electronic address:
Background: Although epigenomic and environment interactions (Epigenome × Environment; Epi × E) might constitute a novel mechanism underlying reward processing direct evidence is still scarce. We conducted the first longitudinal study to investigate the extent to which DNA methylation of a stress-related gene-NR3C1-interacts with childhood maltreatment in association with young adult reward responsiveness (RR) and the downstream risk of depressive (anhedonia dimension in particular) and anxiety symptoms.
Method: A total of 192 Chinese university students aged 18∼25 (M = 21.
Bronchopulmonary dysplasia (BPD) is a chronic lung disease, with its own clinical, radiological and histopathological characteristics, which mainly affects premature newborns, resulting from a combination of factors that include immaturity, inflammation and lung injury, in addition to therapy with mechanical ventilation and exposure to high concentrations of oxygen. However, even with advances in care for critically ill newborns, BPD continues to be a challenge for the care team and family members. This has been identified as one of the most important causes of morbidity and mortality due to prematurity, and can have significant impacts on the quality of life of the affected patients.
View Article and Find Full Text PDFDistinctive Delta and Theta Responses in Deductive and Probabilistic Reasoning.
Brain Behav
January 2025
Research Institute for Health Sciences and Technologies (SABITA), Neuroscience Research Center, Clinical Electrophysiology, Neuroimaging and Neuromodulation Lab, Istanbul Medipol University, Istanbul, Turkey.
Introduction: The neural substrates of reasoning, a cognitive ability we use constantly in daily life, are still unclear. Reasoning can be divided into two types according to how the inference process works and the certainty of the conclusions. In deductive reasoning, certain conclusions are drawn from premises by applying the rules of logic.
View Article and Find Full Text PDFSubthalamic nucleus oscillations during facial emotion processing and apathy in Parkinson's disease.
J Affect Disord
January 2025
Center for Functional Neurosurgery, Department of Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address:
Background: Parkinson's disease (PD) is primarily characterized by motor symptoms, but patients also experience a relatively high prevalence of non-motor symptoms, including emotional and cognitive impairments. While the subthalamic nucleus (STN) is a common target for deep brain stimulation to treat motor symptoms in PD, its role in emotion processing is still under investigation. This study examines the subthalamic neural oscillatory activities during facial emotion processing and its association with affective characteristics.
View Article and Find Full Text PDFAge-related differences in eye blink-related neural activity and functional connectivity during driving.
Heliyon
January 2025
Department of Ergonomics, Leibniz Research Centre for Working Environment and Human Factors, 44139, Dortmund, Germany.
Article Synopsis
- Driving involves complex coordination that deteriorates with age, affecting cognitive and motor functions.
- A study compared blink behavior and neural responses in younger and older adults during reactive and proactive driving tasks, revealing that younger participants had shorter blink durations and more efficient neural processing.
- Functional connectivity analysis indicated that younger adults exhibit stronger network integration in various brain areas, while older adults showed signs of compensatory mechanisms in attention networks, suggesting adaptability in response to cognitive demands.
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