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Impact of sex hormones on pheochromocytomas, paragangliomas, and gastroenteropancreatic neuroendocrine tumors.
Eur J Endocrinol
January 2025
Department of Internal Medicine IV, LMU University Hospital, LMU Munich, 80336 Munich, Germany.
Objective: The effects of sex hormones remain largely unexplored in pheochromocytomas and paragangliomas (PPGLs) and gastroenteropancreatic neuroendocrine tumors (GEP-NETs).
Methods: We evaluated the effects of estradiol, progesterone, Dehydroepiandrosterone sulfate (DHEAS), and testosterone on human patient-derived PPGL/GEP-NET primary culture cell viability (n = 38/n = 12), performed next-generation sequencing and immunohistochemical hormone receptor analysis in patient-derived PPGL tumor tissues (n = 36).
Results: In PPGLs, estradiol and progesterone (1 µm) demonstrated overall significant antitumor effects with the strongest efficacy in PPGLs with NF1 (cluster 2) pathogenic variants.
Comprehensive pan-cancer analysis of CD73: Explore its association with prognosis and tumor immune microenvironment.
Heliyon
November 2024
Department of Clinical Laboratory, The First Affiliated Hospital of Xi'an JiaoTong University, Xi'an, 710061, China.
Article Synopsis
- CD73 is an important molecule involved in immune regulation and its role in the tumor microenvironment was investigated using multiple cancer databases, revealing elevated levels in several cancer types like esophageal carcinoma and glioblastoma.
- The study found that high CD73 expression was often linked to poor overall survival in various cancers such as breast and lung cancers, although in some cases (like kidney and uterine cancers), high expression was associated with better outcomes.
- Additionally, tumors with high CD73 expression showed increased immune scores and positive correlations with immune cell infiltration, indicating a complex relationship between CD73 and the immune response in tumors.
Gastrointestinal stromal tumor in Carney's triad with laparoscopic total gastrectomy: a case report.
Surg Case Rep
October 2024
Hyogo Amagasaki General Center, Amagasaki, Japan.
Article Synopsis
- Carney's triad is a rare syndrome featuring the presence of gastric gastrointestinal stromal tumors (GIST), pulmonary chondromas, and extra-adrenal paragangliomas, as illustrated by a case study of a 28-year-old woman.
- The patient was diagnosed with multiple gastric tumors and a lung nodule during a routine check-up, leading to a total gastrectomy after discovering metastasis in lymph nodes.
- Post-surgery, despite refusing adjuvant therapy, she has been disease-free for 2 years, highlighting the need for careful surgical intervention in similar cases.
Subclinical paraganglioma of the retroperitoneum: A case report.
World J Clin Cases
May 2024
Department of Hepatobiliary and Pancreatic Surgery, Puer People's Hospital, Puer 665000, Yunnan Province, China.
Background: Paraganglioma (PGL) located in the retroperitoneum presents challenges in diagnosis and treatment due to its hidden location, lack of specific symptoms in the early stages, and absence of distinctive manifestations on imaging.
Case Summary: A 56-year-old woman presented with a left upper abdominal mass discovered 1 wk ago during a physical examination. She did not have a history of smoking, alcohol consumption, or other harmful habits, no surgical procedures or infectious diseases, and had a 4-year history of hypertension.
Gastric paraganglioma: a case report and review of literature.
Front Oncol
April 2024
Department of Surgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Article Synopsis
- Paragangliomas (PGLs) are unusual tumors that make extra amounts of certain hormones called catecholamines and are found outside the adrenal glands.
- A 72-year-old man had stomach pain and other health problems for over a year, and doctors discovered he had this rare tumor after doing some scans and surgeries.
- After removing the tumor, his hormone levels returned to normal, and this report shares his case along with information from other similar cases to help understand how to treat gastric paragangliomas better.
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