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Trifluoroacetic acid (TFA) is a persistent and mobile substance that has been increasing in concentration within diverse environmental media, including rain, soils, human serum, plants, plant-based foods, and drinking water. Currently, TFA concentrations are orders of magnitude higher than those of other per- and polyfluoroalkyl substances (PFAS). This accumulation is due to many PFAS having TFA as a transformation product, including several fluorinated gases (F-gases), pesticides, pharmaceuticals, and industrial chemicals, in addition to direct release of industrially produced TFA.

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Pesticides can be a substantial source of trifluoroacetate (TFA) to water resources.

Environ Int

November 2024

Environmental Technology, Wageningen University, P.O. Box 17, 6700 AA Wageningen, The Netherlands. Electronic address:

Through the application of C-CF-containing plant protection products (PPP) in agriculture, a substantial quantity of trifluoroacetate (TFA) can be formed and emitted. We here present estimations of TFA formation potentials from PPP across three important economical regions, namely Europe, the United States of America and China. PPP with TFA formation potential vary in type and use profile across those regions, but can be found throughout, with the estimated maximum TFA emissions ranging from 0 to 83 kg/km per year.

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Acute ischemic stroke (AIS) is the second leading cause of death globally. No Food and Drug Administration (FDA) approved therapies exist that target cerebroprotection following stroke. Our group recently reported significant cerebroprotection with the adenosine A1/A3 receptor agonist, AST-004, in a transient stroke model in non-human primates (NHP) and in a preclinical mouse model of traumatic brain injury (TBI).

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Fluorochemicals are persistent, bioaccumulative, and toxic compounds that are widely tributed in the environment. Developing efficient biodegradation strategies to decompose the fluorochemicals via breaking the inert C-F bonds presents a holistic challenge. As a promising biodegradation enzyme candidate, fluoroacetate dehalogenase (FAcD) has been reported as the only non-metallic enzyme to catalyze the cleavage of the strong C-F bond.

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