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Laminaria japonica polysaccharide protects against liver and kidney injury in diabetes mellitus through the AhR/CD36 pathway.
J Food Sci
February 2025
Medical School, Linyi University, Linyi, Shandong, China.
The lipid accumulation associated with diabetes causes continuous liver and kidney damage. Laminaria japonica polysaccharide (fucoidan) has been shown to regulate the disorder in lipid metabolism caused by diabetes. Herein, we established a diabetes mellitus (DM) rat model through a high-fat and high-sugar diet combined with streptozotocin.
View Article and Find Full Text PDFTranscriptomics-based analysis reveals hexafluoropropylene oxide trimer acid (HFPO-TA) induced kidney damage and lipid metabolism disorders in SD rats.
Ecotoxicol Environ Saf
September 2024
School of Public Health, Bengbu Medical University, Bengbu 233030, PR China. Electronic address:
Hexafluoropropylene oxide trimer acid (HFPO-TA) is an emerging environmental pollutant that can accumulate in air and surface water. Currently, it has been widely used in fluoropolymer industry, which could cause serious environmental pollution. Due to the high bioaccumulation, the accumulation of pollutants may have an adverse effect on the normal physiological function of the kidneys.
View Article and Find Full Text PDFComparative Analysis of Decellularization Methods for the Production of Decellularized Umbilical Cord Matrix.
Curr Issues Mol Biol
July 2024
National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China.
The importance of decellularized extracellular matrix (dECM) as a natural biomaterial in tissue engineering and regenerative medicine is rapidly growing. The core objective of the decellularization process is to eliminate cellular components while maximizing the preservation of the ECM's primary structure and components. Establishing a rapid, effective, and minimally destructive decellularization technique is essential for obtaining high-quality dECM to construct regenerative organs.
View Article and Find Full Text PDF[F] AlF-NOTA-FAPI-04 PET/CT for non-invasive assessment of tubular injury in kidney diseases.
Clin Kidney J
May 2024
Department of Nuclear Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Background: [F] AlF-NOTA-FAPI-04 is a novel positron emission tomography (PET) ligand, which specifically targets fibroblast activation protein (FAP) expression as a FAP inhibitor (FAPI). We analysed the diagnostic value of [F] AlF-NOTA-FAPI-04 PET/CT for the non-invasive assessment of kidney interstitial inflammation and fibrosis in different renal pathologies.
Methods: Twenty-six patients (14 males and 12 females; mean age, 50.
The Footprints of Mitochondrial Fission and Apoptosis in Fluoride-Induced Renal Dysfunction.
Biol Trace Elem Res
September 2024
Henan Key Laboratory of Environmental and Animal Product Safety, Henan University of Science and Technology, Kaiyuan Avenue 263, Luoyang, 471000, Henan, People's Republic of China.
Fluoride (F) is widely distributed in the environment and poses serious health risks to humans and animals. Although a good body of literature demonstrates a close relationship between F content and renal system performance, there is no satisfactory information on the involved intracellular routes. Hence, this study used histopathology and mitochondrial fission to explore fluorine-induced nephrotoxicity further.
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