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Alkaline phosphatase decline and pain response as predictors of overall survival benefit in patients treated with radium-223: a post hoc analysis of the REASSURE study.
Br J Cancer
January 2025
Mayo Clinic, Rochester, MN, USA.
Background: Alkaline phosphatase (ALP) declines and pain responses can occur during radium-223 (Ra) treatment, but their association with treatment outcomes is unclear.
Methods: For patients with metastatic castration-resistant prostate cancer treated with Ra in the REASSURE study, we investigated whether ALP decline (Week 12) and/or pain response (during treatment) are associated with improved overall survival (OS). The Brief Pain Inventory-Short Form (BPI-SF) was used to assess pain at baseline and pain response (in patients with baseline BPI-SF score ≥2).
Surface S-Doped Nanostructured RuO and Its Anion Passivating Effect for Efficient Overall Seawater Splitting.
ACS Nano
January 2025
State Key Laboratory of Silicate Materials for Architectures & State Key Laboratory of Advanced Technology for Materials Synthesis and Processing & School of Chemistry, Chemical Engineering and Life Sciences & Laoshan Laboratory & School of Materials Science and Engineering & International School of Materials Science and Engineering, Wuhan University of Technology, Wuhan 430070, China.
Electrolysis of seawater for hydrogen (H) production to harvest clean energy is an appealing approach. In this context, there is an urgent need for catalysts with high activity and durability. RuO electrocatalysts have shown efficient activity in the hydrogen and oxygen evolution reactions (HER and OER), but they still suffer from poor stability.
View Article and Find Full Text PDFExtraction of high-purity lignin from the kraft pulping black liquor by enzyme purification process with alkaline-resistant xylanase and cellulase.
Int J Biol Macromol
January 2025
Shandong Huatai Paper Co., Ltd. & Shandong Yellow Triangle Biotechnology Industry Research Institute Co. LTD, Dongying 257335, China.
In this study, the response surface methodology was first utilized to optimize the enzyme treatment conditions as reaction pH, temperature, time and enzyme dosage of 9.5, 45 °C, 94.5 min and 100 U/L.
View Article and Find Full Text PDFThe Effects of Morphology and Hydration on Anion Transport in Self-Assembled Nanoporous Membranes.
ACS Nano
January 2025
Department of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.
Ordered nanoporous polymer membranes offer opportunities for systematically probing the mechanisms of ion transport under confinement and for realizing useful materials for electrochemical devices. Here, we examine the impact of morphology and ion hydration on the transport of hydroxide and bromide anions in nanostructured polymer membranes with 1 nm scale pores. We use aqueous lyotropic self-assembly of an amphiphilic monomer, with a polymerizable surfactant to create direct hexagonal (H) and gyroid mesophases.
View Article and Find Full Text PDFBpMYB06 Acts as a Positive Regulatory Factor in Saline-alkaline Stress Resistance by Binding to Two Novel Elements.
Plant Cell Physiol
December 2024
The Key Laboratory of Forest Tree Genetics, Breeding and Cultivation of Liaoning Province, Shenyang Agricultural University, Shenyang, Liaoning 110866, China.
Saline-alkaline salinity is recognized as one of the most severe abiotic stress factors, limiting plant growth and resulting in significant yield losses. MYB transcription factors (TFs) are crucial for plant tolerance to abiotic stress. However, the roles and regulatory mechanism of MYB TFs underlying saline-alkaline stress tolerance has not yet been investigated in Betula platyphylla.
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