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Stereospecific Radical Bromination of β-Aryl Alcohols with Thiourea Additives Through A Serendipitous Discovery of A 1,2-Aryl Migration.
Chemistry
January 2025
Department of Natural Sciences, The Open University of Israel, Ra'anana 4353701, Israel.
The development of new protocols for stereospecific and stereoselective halogenation transformations by mild reaction conditions is a highly desirable research target for the chemical and pharmaceutical industries. Following the straightforward methodology for directly transforming a wide scope of alcohols to alkyl bromides and chlorides using substoichiometric amounts of thioureas and N-halo succinimides (NXS) as a halogen source in a single step, we noticed that in apolar solvents bromination of chiral secondary alcohols did not produce the expected racemates. In this study, the stereochemical aspects of the bromination reaction were examined.
View Article and Find Full Text PDFUpdate/Refinement of Targeted Muscle Reinnervation Indication: A Scoping Review of Applications for Non-Amputees.
J Clin Med
October 2024
Department of Plastic and Reconstructive Surgery, Pasteur University Hospital, 06000 Nice, France.
Targeted muscle reinnervation (TMR) was originally developed to enhance prosthetic control in amputees. However, it has also serendipitously demonstrated benefits in reducing phantom pain and neuromas. As a result, it has emerged as a secondary treatment for chronic neuromas in amputees and holds promise for managing neuropathic pain in non-amputee patients, particularly those with neuromas.
View Article and Find Full Text PDFCancer-induced systemic pre-conditioning of distant organs: building a niche for metastatic cells.
Nat Rev Cancer
December 2024
Tumour-Host Interaction Laboratory, The Francis Crick Institute, London, UK.
Article Synopsis
- Tumour cells integrate with normal surrounding cells and establish connections through blood, lymphatic vessels, and neural pathways, creating an abnormal structure within the host organism.
- These connections allow tumours to send signals that disturb body functions, facilitating the formation of early metastatic niches in distant tissues where cancer cells can thrive.
- The review discusses the mechanisms by which primary tumours condition distant organs for metastasis and emphasizes the need for a comprehensive understanding of these processes to identify potential preventive or therapeutic strategies.
Triphallia: the first cadaveric description of internal penile triplication: a case report.
J Med Case Rep
October 2024
University of Birmingham Medical School, Edgbaston, Birmingham, West Midlands, B15 2TT, UK.
Introduction: Triphallia, a rare congenital anomaly describing the presence of three distinct penile shafts, has been reported only once in the literature. This case report, based on an extensive literature review, describes the serendipitous discovery during cadaveric dissection of the second reported human case of triphallia, distinctly morphologically different from the previous case.
Case Presentation: Despite the normal appearance of external genitalia on examination, the dissection of a 78-year-old white male revealed a remarkable anatomical variation: two small supernumerary penises stacked in a sagittal orientation posteroinferiorly to the primary penis.
Investigation of Markedly Elevated Liver Enzymes With Serendipitous Underlying Wilson's Disease With Chronic Alcohol Abuse.
Cureus
April 2024
Internal Medicine, Eastern Maine Medical Center, Bangor, USA.
Acute hepatitis can result from a wide variety of noninfectious causes that include, but are not limited to, drugs (drug-induced hepatitis), alcohol (alcoholic hepatitis), immunologic (autoimmune hepatitis, primary biliary cholangitis), or as a result of indirect insult secondary to biliary tract dysfunction (cholestatic hepatitis), pregnancy-related liver dysfunction, shock, or metastatic disease. In clinical settings, these causes are not uncommon to overlap with each other or are masked by obviously visible causes in medical history. We reported our scenario of a patient who has a heavy history of alcohol use and presented with alcohol withdrawal symptoms and a marked elevation of liver enzymes.
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