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Analysis of the Results of Tuberculosis Drug Resistance Surveillance in Yuexiu District, Guangzhou City, 2013-2022.
Immun Inflamm Dis
November 2024
State Key Laboratory of Respiratory Disease, Guangzhou Key Laboratory of Tuberculosis, Guangzhou Chest Hospital, Institute of Tuberculosis, Guangzhou Medical University, Guangzhou, China.
Article Synopsis
- The study investigates drug resistance trends in tuberculosis patients in Yuexiu District, Guangzhou City, over a nine-year period from 2013 to 2022 to inform better prevention and control strategies.
- Out of 5,191 active tuberculosis patients analyzed, 1,659 Mycobacterium tuberculosis strains were cultured, resulting in 438 cases of drug resistance.
- The overall drug resistance rate was 26.40%, with significant findings including 15.37% monoresistance, 7.29% polyresistance, and 3.74% multidrug resistance, with the highest resistance observed to streptomycin and isoniazid.
Hepatoprotective potential of alpha-lipoic acid against gliclazide-induced liver injury in high-glucose-exposed human liver cells and experimental type 2 diabetic rats.
Biochem Pharmacol
September 2024
Department of Medical Pharmacology, University of Ghana Medical School, Korle-Bu, Accra, Ghana.
Growing clinical evidence shows that sulfonylurea therapy for patients with type 2 diabetic mellitus (T2DM) contributes to progressive worsening of their liver. The present study presents hepatotoxicity induced by gliclazide, a second-generation sulfonylurea, and alpha-lipoic acid (ALA) as a novel and promising drug for T2DM treatment. Normal human liver cells (HL-7702) were incubated with high-glucose DMEM in the presence or absence of gliclazide and ALA for 72 h, and cell viability and death were measured by flow cytometry.
View Article and Find Full Text PDFIn vitro Antibacterial Effect Study of Plasma-Activated Saline on .
Infect Drug Resist
June 2024
Center for Plasma Biomedicine, State Key Laboratory of Electrical Insulation and Power Equipment, Xi'an Jiaotong University, Xi'an, 710049, People's Republic of China.
Purpose: This study aimed to investigate the antibacterial effects of plasma-activated saline (PAS) on My-cobacterium tuberculosis (Mtb).
Methods: We conducted a growth assay on 3 strains of Mtb and an antibiotic sensitivity test on 4 strains of Mtb. Both tests included groups treated with normal saline (NS), PAS, and hydrochloric acid (HCl).
A novel HIF2A mutation causes dyslipidemia and promotes hepatic lipid accumulation.
Pharmacol Res
August 2023
State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Rd., Hangzhou City 310003, China; National Clinical Research Center for Infectious Diseases, Hangzhou City 310003, China; Jinan Microecological Biomedicine Shandong Laboratory, Jinan City 250117, China.
Hypoxia-inducible factor-2α (HIF-2α) is a transcription factor responsible for regulating genes related to angiogenesis and metabolism. This study aims to explore the effect of a previously unreported mutation c.C2473T (p.
View Article and Find Full Text PDFAntimicrobial-Resistant in Ready-to-Eat Foods: Implications for Food Safety and Risk Assessment.
Foods
March 2023
Applied and Environmental Microbiology Research Group (AEMREG), Department of Biochemistry and Microbiology, University of Fort Hare, Private Bag X1314, Alice 5700, South Africa.
Antimicrobial resistance is an existential threat to the health sector, with far-reaching consequences in managing microbial infections. In this study, one hundred and ninety-four isolates were profiled for susceptibility using disc diffusion techniques. Possible foodborne listeriosis risk associated with ready-to-eat (RTE) foods (RTEF) and the risk of empirical treatment (EMPT) of infections, using multiple antimicrobial resistance indices (MARI) and antimicrobial resistance indices (ARI), respectively, were investigated.
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