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Atypical "accelerated" chronic lymphocytic leukemia with abnormal lymphocyte chromatin clumping, bone involvement, and exceptional response to Imbruvica.
Cancer Rep (Hoboken)
September 2022
Oncology Division, Kaiser Permanente San Jose Medical Center, San Jose, California, USA.
Background: The "accelerated" chronic lymphocytic leukemia (aCLL) is a relatively rare form of CLL progression. The expanded proliferation centers in aCLL have been associated with adverse prognostic features and propensity to more aggressive behavior with shorter survival.
Case: An atypical case of aCLL with distinct features is described.
Familial Pelger-Huet Anomaly.
Indian J Hematol Blood Transfus
June 2016
Laboratory, Bhatia Hospital, 2nd Floor, Tukaram Javji Road, Tardeo, Mumbai, 400007 India.
Pelger-Huet anomaly is usually autosomal dominant, although it is likely that new mutations are common. This condition is characterized by granulocytes that are either bilobed or completely unsegmented. Here is a report of a 46 year old Indian lady who presented with fever to the hospital and on evaluation, her peripheral blood smear showed extreme hypolobation of granulocytes.
View Article and Find Full Text PDFThe pseudo-Pelger-Huët anomaly in pyoderma gangrenosum associated with myelodysplastic syndrome.
Am J Dermatopathol
June 2007
Department of Dermatology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA.
We report a case of pyoderma gangrenosum in which most of the neutrophils exhibited the pseudo-Pelger-Huët (pPH) anomaly, a cytologic abnormality affecting the neutrophil nucleus. Pelgeroid cells have round, oval, or hyposegmented nuclei and are therefore difficult to recognize as neutrophils. The pPH anomaly is important because it is found mostly in patients with myelodysplastic syndromes or myeloid leukemias.
View Article and Find Full Text PDFPelgeroid-like anomalous cells in the diagnosis of neutrophilic dermatosis associated with myelodysplastic syndrome.
Int J Dermatol
December 1992
Department of Dermatology, Tokyo Women's Medical College, Japan.
Neutrophilic dermatoses (ND), with or without accompanying myelodysplastic syndrome (MDS), were examined in terms of nuclear abnormality like pelgeroid anomaly of infiltrating cells into skin lesions. Six ND accompanying MDS showed 1.0 to 13.
View Article and Find Full Text PDFA variant myelodysplastic syndrome with multilineage Pelgeroid chromatin.
Am J Clin Pathol
February 1986
An unusual myelodysplastic syndrome with similar features in two patients is described. The entity is characterized by a maturation arrest at the myelocyte stage, strikingly clumpy chromatin, and a clinical course marked primarily by difficulties caused by anemia and thrombocytopenia. Electron microscopic description of the characteristic abnormal clumpy chromatin cells is included.
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