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Preclinical Benefit of Hypoxia-Activated Intra-arterial Therapy with Evofosfamide in Liver Cancer.
Clin Cancer Res
January 2017
Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, Connecticut.
Purpose: To evaluate safety and characterize anticancer efficacy of hepatic hypoxia-activated intra-arterial therapy (HAIAT) with evofosfamide in a rabbit model.
Experimental Design: VX2-tumor-bearing rabbits were assigned to 4 intra-arterial therapy (IAT) groups (n = 7/group): (i) saline (control); (ii) evofosfamide (Evo); (iii) doxorubicin-lipiodol emulsion followed by embolization with 100-300 μm beads (conventional, cTACE); or (iv) cTACE and evofosfamide (cTACE + Evo). Blood samples were collected pre-IAT and 1, 2, 7, and 14 days post-IAT.
A multicenter phase I dose escalation trial to evaluate safety and tolerability of intra-arterial temozolomide for patients with advanced extremity melanoma using normothermic isolated limb infusion.
Ann Surg Oncol
January 2015
Department of Surgery, Duke University Medical Center, Durham, NC, USA,
Background: L-phenylalanine mustard (LPAM) has been the standard for use in regional chemotherapy (RC) for unresectable in-transit melanoma. Preclinical data demonstrated that regional temozolomide (TMZ) may be more effective.
Methods: Patients with AJCC Stage IIIB or IIIC extremity melanoma who failed previous LPAM-based RC were treated with TMZ via isolated limb infusion (ILI) according to a modified accelerated titration design.
Non-contact mapping guided cardiac resynchronization therapy for a failing systemic right ventricle.
Europace
October 2007
The Wessex Cardiothoracic Unit, Division of Clinical Electrophysiology, Southampton University Hospitals NHS Trust, Southampton General Hospital, Southampton SO16 6YD, Hampshire, UK.
Aims: Progressive systemic right ventricular (sRV) dysfunction, atrial and ventricular arrhythmias and sudden cardiac death are well-recognized late sequelae of atrial redirection surgery in which the right ventricle is left connected to the systemic circulation. Although cardiac resynchronization therapy (CRT) poses an attractive therapeutic option, little is known about indications, patient selection, and technical aspects of best lead placement.
Methods And Results: We undertook CRT in a 27-year-old female patient post-Mustard correction for d-transposition (d-TGA) with New York Heart Association (NYHA) grade III disability with QRS duration measuring 130 ms.
[Clinical effects of intra-arterial nitrogen mustard (NH2) chemotherapy during operation for oral cancer].
Hua Xi Kou Qiang Yi Xue Za Zhi
February 2000
School of Stomatology, Shanghai Second Medical University.
Objective: To discuss the general and local side-effects and clinic appliance of the intra-arterial chemotherapy, and evaluate the short-time clinic effects of the intra-arterial chemotherapy.
Methods: From February, 1997 to December, 1997 11 patients with oral cancer (9 cases with lingual carcinoma, 2 cases with mouth carcinoma) were received one-shot chemotherapy during operation by NH2 catheterizing of lingual arteries (concentration of 1 mg/ml, dosage of 5 mg), and the other 16 oral cancer patients (13 cases with lingual carcinoma, 3 cases with mouth carcinoma) were only received operation as the control. At the same time, all patients were treated with Chinese flaps or Major pectoris myocutanous flaps homochronously.
Galanin mediated inhibitory nervous modulation of cutaneous vascular reactions.
Acta Physiol Hung
September 2000
Department of Physiology, Szent-Györgyi Albert Medical University, Szeged, Hungary.
Noxious stimulation induces local inflammatory responses in a variety of mammals but these reactions are only faint in avian species. The possibility that endogenous galanin inhibits neurogenic vascular responses in avians was tested in the wing skin of anaesthetized pigeons. Intraarterial infusion of nanomolar concentrations of the specific galanin antagonist M35 dose dependently enhanced the small mustard oil induced increase of skin blood flow measured by means of a Laser Doppler Imager.
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