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| http://dx.doi.org/10.1136/bmj.2.4844.1019 | DOI Listing |
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Occurrence and characteristics of endoscopic gastric polyps in patients with autoimmune gastritis (AGAPE study): A multicentric cross-sectional study.
Dig Liver Dis
January 2025
Gastroenterology and Endoscopy, IRCCS Ospedale San Raffaele, Milan, Italy, and Vita-Salute San Raffaele University, Milan, Italy.
Article Synopsis
- Autoimmune gastritis (AIG) causes higher gastrin levels, leading to changes in the gastric mucosa and an increased risk of developing gastric polyps.
- A study involving 612 AIG patients over a median of 4 years found that 36.3% developed gastric polyps, with various types identified, including inflammatory and adenomatous types, along with some cases of gastric neuroendocrine neoplasms (gNENs) and adenocarcinomas.
- The findings highlight the need for regular endoscopic monitoring and histopathological assessments in AIG patients due to the significant risk of gastric polyps and related complications.
Multiple gastric neuroendocrine tumors in a patient with parietal cell dysfunction and adenosine triphosphatase H/K transporting subunit alpha gene variant.
Clin J Gastroenterol
August 2024
Faculty of Medicine, Department of Gastroenterology, Yamagata University, 2-2-2 Iida-Nishi, Yamagata, 990-9585, Japan.
A 47-year-old woman presented with multiple gastric tumors, each up to 10 mm in diameter, in the gastric body and fundus without mucosal atrophy. White spots and numerous transparent, light-brownish, small, and rounded spots were observed in the background gastric mucosa. Biopsy specimens obtained from the tumors revealed gastric neuroendocrine tumors.
View Article and Find Full Text PDFDeterioration of apatite orientation in the cholecystokinin B receptor gene (Cckbr)-deficient mouse femurs.
J Bone Miner Metab
November 2023
Division of Materials and Manufacturing Science, Graduate School of Engineering, Osaka University, 2-1, Yamada-Oka, Suita, Osaka, 565-0871, Japan.
Introduction: The discrepancy between bone mineral density (BMD), the gold standard for bone assessment, and bone strength is a constraint in diagnosing bone function and determining treatment strategies for several bone diseases. Gastric hypochlorhydria induced by clinically used proton pump inhibitor (PPI) therapy indicates a discordance between changes in BMD and bone strength. Here, we used Cckbr-deficient mice with gastric hypochlorhydria to examine the effect of gastric hypochlorhydria on bone mass, BMD, and preferential orientation of the apatite crystallites, which is a strong indicator of bone strength.
View Article and Find Full Text PDFExploring the spectrum of incidental gastric polyps in autoimmune gastritis.
Dig Liver Dis
September 2023
Division of Gastroenterology and Center for Autoimmune Liver Diseases, European Reference Network on Hepatological Diseases (ERN RARE-LIVER), San Gerardo Hospital, ASST Monza, Via G.B. Pergolesi 33, Monza e Della Brianza (MB), Monza, Italy.
Background: Gastric polyps represent an abnormal proliferation of the gastric mucosa. Chronic atrophic autoimmune gastritis (CAAG) targets parietal cells and results in hypo-achlorhydria and hypergastrinemia, which exerts a proliferative effect on the gastric mucosa.
Aims: We investigate the incidence of gastric polyps in CAAG patients.
Prevalence of achlorhydria in an Asian population detected using Congo red staining during routine gastroscopy: 22 years' experience from a single centre.
BMJ Open Gastroenterol
August 2022
Excellence Center for Gastrointestinal Endoscopy, King Chulalongkorn Memorial Hospital, Bangkok, Thailand
Article Synopsis
- The study aimed to investigate the prevalence of achlorhydria (AC) in a large Asian population by reviewing medical records of patients who underwent an oesophagogastroduodenoscopy (OGD) from 2010 to 2019.
- Out of 3374 patients, only 18 (0.53%) were found to have AC; 7 had permanent AC and 11 had temporary AC, often associated with gastrointestinal bacterial infections and older age.
- The findings suggest that AC is rare, primarily occurring in older adults, and recommend using Congo red staining during OGD for early detection, along with low-cost screening for serum vitamin B levels in patients aged 50 and over.
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