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Activation of Local 11β-Hydroxysteroid Dehydrogenase Type 1 by Diosmetin Enhances Endogenous Glucocorticoid Levels to Alleviate Skin Inflammation: Insights Into a Novel Therapeutic Strategy for Atopic Dermatitis.
Exp Dermatol
February 2025
Department of Dermatology, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea.
Glucocorticoids (GCs) are synthesised de novo by peripheral tissues and the adrenal cortex of the hypothalamic-pituitary-adrenal axis. Skin expresses an enzyme called 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), which reduces cortisone to the active hormone cortisol which activates GC receptors. 11β-HSD1 plays a significant role in alleviating atopic inflammation through the elevation of the concentrations of active GC in the skin.
View Article and Find Full Text PDFReal-world clinical and economic impacts of delayed rotator cuff repair surgery in Japan: analysis of a large claims database.
JSES Rev Rep Tech
February 2025
Smith & Nephew, Asia Pacific, Singapore, Singapore.
Background: In patients with rotator cuff tears (RCTs), there is a lack of evidence regarding the impact of the timeliness of rotator cuff repair (RCR) surgery on treatment outcomes and overall healthcare burden. This study aimed to understand the impact of early vs. delayed RCR on real-world healthcare costs and resource use (HCRU) in Japan.
View Article and Find Full Text PDFRole of 11β-hydroxysteroid dehydrogenase type 1 inhibition in the antiobesity effect of J2H-1702 on adipocytes and a high-fat diet-induced NASH model.
Eur J Pharmacol
February 2025
College of Korean Medicine, Gachon University, Seongnam, 13120, South Korea. Electronic address:
Obesity due to excessive body fat accumulation remains a global problem. Patients with obesity have high cortisol levels, and its dysregulation is caused by increased 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) levels. The effects and mechanism of J2H-1702, an 11β-HSD1 inhibitor, on nonalcoholic steatohepatitis (NASH) were explored.
View Article and Find Full Text PDFA feasibility study on cortisol and cortisone as biomarkers for psychological stress in wastewater-based epidemiology.
Water Res
December 2024
College of Environmental Science and Engineering, Dalian Maritime University, No. 1 Linghai Road, Dalian, , 116026, China. Electronic address:
Psychological stress has a significant impact on individuals' quality of life and health. Traditionally, psychological stress assessment relies on self-reported tools such as the Perceived Stress Scale (PSS), which are inherently subjective. This study aims to evaluate the feasibility of using wastewater-based epidemiology (WBE) to assess cortisol and cortisone as biomarkers for psychological stress.
View Article and Find Full Text PDFEfficacy of Cortisone Injection in Foot and Ankle Osteoarthritis.
Cureus
November 2024
Orthopaedics, Stepping Hill Hospital, Manchester, GBR.
Osteoarthritis (OA) of the foot and ankle is prevalent and often debilitating, necessitating effective treatment options. This study evaluates the analgesic efficacy of corticosteroid injections in individual foot and ankle joints. Stepping Hill Hospital conducted a retrospective audit of 166 patients who received guided corticosteroid injections.
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