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Intravenous Regeneration-associated Cell Transplantation Enhances Tissue Recovery in Mice with Acute Ischemic Stroke.
Keio J Med
November 2024
Department of Neurology, Tokai University School of Medicine, Isehara, Japan.
Previously, we reported that transplantation of regeneration-associated cells (RACs) via the ipsilateral external carotid artery reduced stroke volume in mice with permanent occlusion of the middle cerebral artery (MCA). However, intracarotid arterial transplantation is invasive and requires skill, and severe complications may occur, such as thromboembolism, infection, and decreased cerebral blood flow. This study aimed to investigate the efficacy of intravenous injection of RACs in reducing stroke volume and increasing anti-inflammatory and angiogenic factors in mice with focal cerebral ischemia.
View Article and Find Full Text PDFInhibition of matrix metalloproteinases to reduce blood brain barrier disruption and haemorrhagic transformation in ischaemic stroke: Go broad or go narrow?
Neuropharmacology
January 2025
School of Pharmacy and Bioengineering, Keele University, Staffordshire, ST5 5BG, UK. Electronic address:
Article Synopsis
- Ischaemic stroke is caused by blockage of small arteries in the brain, leading to brain tissue damage, cognitive problems, and sometimes permanent injury.
- Current treatments like thrombolysis and thrombectomy can worsen the risk of hemorrhage due to damage to blood vessels, with matrix metalloproteinases (MMPs) playing a key role in this process.
- Inhibiting MMPs shows promise in reducing brain damage and improving outcomes in stroke patients, but there are challenges regarding how and when to use these inhibitors effectively, and they are not yet an approved therapy.
In Vivo Feasibility of Arterial Embolization with a New Permanent Agar-agar-Based Agent.
Cardiovasc Intervent Radiol
February 2025
Interventional Radiology Section, Department of Medical Imaging, University Hospital Timone, AP-HM, 264 Rue Saint-Pierre, 13005, Marseille, France.
Purpose: Evaluate the safety and efficacy of an eco-friendly permanent agar-agar-based embolization agent (ABEA) (EmboBio®) for intra-arterial use.
Materials And Methods: Six pigs embolized with one ABEA torpedo (6 lower polar renal and 6 lumbar arteries) and one coil (6 lower polar renal and 6 lumbar arteries). Technical success was defined as a complete occlusion with no residual flow in DSA.
Engraftment of human mesenchymal stem cells in a severely immunodeficient mouse.
Inflamm Regen
September 2024
Department of Biochemistry, Faculty of Medicine, Shimane University, 89-1 Enya, Izumo City, Shimane, 693-8501, Japan.
The transplantation of human mesenchymal stromal/stem cells (hMSCs) has potential as a curative and permanent therapy for congenital skeletal diseases. However, the self-renewal and differentiation capacities of hMSCs markedly vary. Therefore, cell proliferation and trilineage differentiation capacities were tested in vitro to characterize hMSCs before their clinical use.
View Article and Find Full Text PDF177 Lu-Microspheres Selective Intra-arterial Radionuclide Therapy : A Facile and Biocompatible Permanent Micro-Seed Implants for Unresectable Hepatocellular Carcinoma.
Clin Nucl Med
April 2024
From the Department of Nuclear Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh.
Hepatocellular carcinoma (HCC) is an aggressive malignancy with a poor prognosis. Surgical resection is limited. Selective intra-arterial radionuclide therapy (SIRT) emerged as a potential cure for intermediate HCC with portal vein thrombosis.
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