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The Chondrogenic Potential of the Bovine Tendon Sheath - a Novel Source of Stem Cells for Cartilage Repair.
Stem Cells
December 2024
Department of Plastic and Hand Surgery, Inselspital Bern University Hospital, Bern, Switzerland.
The human hand is traumatized more frequently than any other bodily part. Trauma and pathological processes (e.g.
View Article and Find Full Text PDF[Human-animal chimeras. A systematic review of the ethical problems they raise and their possible solutions.].
Cuad Bioet
November 2023
Instituto de Ciencias de la Vida. Universidad Católica de Valencia San Vicente Mártir. Valencia. Spain.
Human-animal chimera research has gradually evolved to the present day, in which large projects related to the attempt to solve pathologies that help us human beings to alleviate diseases. However, it must be considered that many of these advances in science imply an important ethical dilemma in many cases, and even more so if we involve people in said experiments. In the present systematic review we sought to identify these ethical problems related to chimeras, as well as possible solutions to them proposed in the literature, including technical means for the realization of less humanized chimeras.
View Article and Find Full Text PDF's Ingredients Improve Control of the Hepatic Lipid Disturbances Derived from a High-Fat Diet.
Foods
September 2023
Molecular Immunonutrition Group, Madrid Institute for Advanced Studies in Food (IMDEA-Food), 28049 Madrid, Spain.
This study explored the effects of 's ingredients on the major lipids' hepatic profile and the functional selective differentiation of monocyte-derived macrophages and innate lymphoid cells in mice on a high-fat diet. Six-week-old Rag2 and Rag2Il2 mice received (12 days) a low-molecular-weight protein fraction (LWPF) or the lipid fraction (qLF) obtained from the cold pressing of 's germen. At the end of the experiment, mouse serum and liver tissue were collected.
View Article and Find Full Text PDFNovel concept of Wilms' tumor development: involvement of pluripotential cells of ureteric bud.
Hum Pathol
August 2023
Department of Urology, Medical School, University of Pecs, 7621, Pecs, Hungary; Medical Faculty, Ruprecht-Karls-University, 69120, Heidelberg, Germany. Electronic address:
It is acknowledged that nephron develops after bilateral induction of the metanephric mesenchyma and branching ureteric bud (UB), and that nephrogenic rest and Wilms' tumor (nephroblastoma) arises from impaired differentiation of metanephric blastema. The aim of this study was to obtain more information on the involvement of UB derivatives in nephrogenic rest and Wilms' tumor. We applied immunohistochemistry to analyze nephrogenic rests and Wilms' tumors with mixed histology, including regressive and blastemal types.
View Article and Find Full Text PDFSpatiotemporal Coordination of RPE Cell Quality by Extracellular Vesicle miR-494-3p Via Competitive Interplays With SIRT3 or PTEN.
Invest Ophthalmol Vis Sci
May 2023
Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Purpose: To reveal the molecular mechanism underlying degeneration in human retinal pigment epithelial (hRPE) cells with dysfunctional mitochondrial homeostasis.
Methods: The expression of recently identified miR-494-3p in extracellular vesicles (EV) released from induced-pluripotential-stem-cell-derived human RPE (iPS-hRPE), during coculture with macrophages (Mps) was investigated in iPS-hRPE and ARPE cells differentiated in the presence of nicotinamide (Nic-ARPE). The expression of phosphatase and tensin homolog (PTEN), sirtuin3 (SIRT3), and mitochondrial marker proteins before and after the transfection of miR-494-3p inhibitor and mimic, and the changes in mitochondrial metabolism, membrane potential, and oxidative phosphorylation (OXPHOS) were monitored.
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