Intraperitoneal cyclophosphamide administration to a total dose of 225 mg/kg body weight during six weeks produced in rat myocardial fibres evident focal degenerative changes in all organelles, and, fairly frequently, significant damage even up to necrosis. The experiment showed that in rats on low-magnesium diet cyclophosphamide produced more intense and more extensive changes than in rats receiving only cyclophosphamide. The extent of the lesions produced with low and high doses of cyclophosphamide was compared and it was observed that the lesions increased with an enlargement of doses of the drug.
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