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A Randomized Controlled Trial to Optimize Antivenom Therapy for Carpet Viper (Echis romani)-Envenomed Children in Nigeria.
Am J Trop Med Hyg
October 2024
Infectious & Tropical Diseases Unit, Bayero University, Kano, Nigeria.
In an open randomized controlled trial, we compared one vial (10 mL) to two vials (20 mL) of EchiTAb-plus-ICP (EPI) antivenom among children with systemic carpet viper (Echis romani) envenoming of moderate severity in northeastern Nigeria. Systemic envenoming, presenting with incoagulable blood, was diagnosed using the 20-minute whole blood clotting test (20WBCT). Eligible patients with positive 20WBCT whose guardians assented were recruited and randomly allocated to receive either one vial or two vials of EPI administered either as a bolus or as a slow continuous infusion.
View Article and Find Full Text PDFIsolation and Functional Characterization of Erythrofibrase: An Alfa-Fibrinogenase Enzyme from Venom of North-East India.
Toxins (Basel)
April 2024
Molecular Toxinology Laboratory, Department of Molecular Biology and Biotechnology, Tezpur University, Tezpur 784028, Assam, India.
Green pit viper bites induce mild toxicity with painful local swelling, blistering, cellulitis, necrosis, ecchymosis and consumptive coagulopathy. Several bite cases of green pit vipers have been reported in several south-east Asian countries including the north-eastern region of India. The present study describes isolation and characterization of a haemostatically active protein from venom responsible for coagulopathy.
View Article and Find Full Text PDFShedding Lights on Crude Venom from Solitary Foraging Predatory Ant : Initial Toxinological Investigation.
Toxins (Basel)
January 2022
Laboratory of Biochemistry and Animal Toxins, Institute of Biotechnology, Federal University of Uberlândia, Uberlândia 38408-100, MG, Brazil.
Some species of primitive predatory ants, despite living in a colony, exercise their hunting collection strategy individually; their venom is painful, paralyzing, digestive, and lethal for their prey, yet the toxins responsible for these effects are poorly known. is a previously unrecorded solitary hunting ant from the Brazilian Cerrado. To overcome this hindrance, the present study performed the in vitro enzymatic, biochemical, and biological activities of to better understand the properties of this venom.
View Article and Find Full Text PDFBleeding and Thrombosis: Insights into Pathophysiology of Venom-Related Hemostasis Disorders.
Int J Mol Sci
September 2021
INSERM, UMRS-1144, Paris University, 75006 Paris, France.
Article Synopsis
- Toxins from venoms can cause serious health issues related to bleeding and clotting disorders, including both local and systemic bleeding problems.
- These venoms contain various types of proteins that can either affect blood coagulation directly or disrupt blood vessel integrity, ultimately leading to conditions like edema and organ failure.
- The mechanisms of these effects include damaging blood vessel structures, altering platelet function, and switching the blood vessel lining to a state that promotes clotting, contributing to both bleeding and thrombosis during envenomation events.
Clinical management of snakebite envenoming: Future perspectives.
Toxicon X
September 2021
Infectious and Tropical Diseases Unit, Bayero University Kano, Nigeria.
Snakebite envenoming is a major cause of morbidity and mortality in rural communities throughout the tropics. Generally, the main clinical features of snakebites are local swelling, tissue necrosis, shock, spontaneous systemic hemorrhage, incoagulable blood, paralysis, rhabdomyolysis, and acute kidney injury. These clinical manifestations result from complex biochemical venom constituents comprising of cytotoxins, hemotoxins, neurotoxins, myotoxins, and other substances.
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