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Opioid-independent mechanisms supporting offset analgesia and temporal sharpening of nociceptive information.
Pain
June 2012
Department of Neurobiology and Anatomy, Wake Forest University School of Medicine, Winston-Salem, NC, USA Department of Anesthesiology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
The mechanisms supporting temporal processing of pain remain poorly understood. To determine the involvement of opioid mechanisms in temporal processing of pain, responses to dynamic noxious thermal stimuli and offset analgesia were assessed after administration of naloxone, a μ-opioid antagonist, and on a separate day, during and after intravenous administration of remifentanil, a μ-opioid agonist, in 19 healthy human volunteers. Multiple end points were sampled from real-time computerized visual analog scale ratings (VAS, 1 to 10) to assess thermal sensitivity, magnitude and duration of offset analgesia, and painful after sensations.
View Article and Find Full Text PDFPsychophysical correlates in adults with sensory modulation disorder.
Disabil Rehabil
June 2012
School of Occupational Therapy, Faculty of Medicine of Hadassah and the Hebrew University of Jerusalem, Jerusalem, Israel.
Purpose: Individuals with sensory modulation disorder (SMD) demonstrate abnormal responses to naturally occurring stimuli in a manner that interferes with daily life activities. This study is the first study applying quantitative sensory testing to characterize the somatosensory sensitivity of adults with SMD.
Method: One hundred and fifty one adults (68 males and 83 females) were tested comparing 91 SMD to 60 SMD-free, control individuals.
Psychophysical correlates in children with sensory modulation disorder (SMD).
Physiol Behav
December 2009
School of Occupational Therapy, Faculty of Medicine of Hadassah and the Hebrew University of Jerusalem, Jerusalem91240, Israel.
Sensory modulation disorder (SMD), affecting approximately 5% of children, is characterized by sensory over or under-responsiveness to a range of stimuli in several modalities. Children with over-responsiveness (SOR) demonstrate increased aversion to certain natural stimuli that manifests as increased distress and avoidance behaviors to common stimuli, accompanied by abnormal electrodermal responses and brain evoked potentials to various stimuli. This study is the first to use quantitative sensory testing to characterize the somatosensory sub-modalities of children with SMD.
View Article and Find Full Text PDFTemporal summation of pain from mechanical stimulation of muscle tissue in normal controls and subjects with fibromyalgia syndrome.
Pain
March 2003
Department of Medicine, McKnight Brain Institute, University of Florida College of Medicine, 1600 SW Archer Rd, PO Box 100221, Gainesville, FL 32610-0221, USA.
Individuals diagnosed with fibromyalgia syndrome (FMS) report chronic pain that is frequently worsened by physical activity and improved by rest. Palpation of muscle and tendinous structures suggests that nociceptors in deep tissues are abnormally sensitive in FMS, but methods of controlled mechanical stimulation of muscles are needed to better characterize the sensitivity of deep tissues. Accordingly, force-controlled mechanical stimulation was applied to the flexor digitorum muscle of the forearm in a series of brief contacts (15 stimuli, each of 1s duration, at 3 or 5s interstimulus intervals).
View Article and Find Full Text PDFSelective reduction of second pain sensations by systemic morphine in humans.
Pain
January 1986
Department of Neuroscience, and Center for Neurobiological Sciences, University of Florida College of Medicine, Gainesville, FL 32610 U.S.A.
A variety of forms of painful stimulation were delivered to human subjects in order to determine whether therapeutic dosages of systemic morphine might produce significant attenuation of some forms of phasic pain that are tolerable for experimental usage. Consistent with previous reports, simple application of thermal or electrical energy to the skin (for 3 sec) produced sensations of pain that were not significantly reduced by prior administration of morphine. Similarly, subjects that were trained to focus their attention on the magnitude of the immediate (first) pain sensation evoked by brief electrical or mechanical stimulation did not report reduction by morphine of pain attributed to conduction in myelinated peripheral nociceptors.
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