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Influence of chronic exposure to treated sewage effluent on the distribution of white blood cell populations in rainbow trout (Oncorhynchus mykiss) spleen.
Toxicol Sci
November 2004
Environmental Toxicology, University of Konstanz, D-78457 Konstanz, Germany.
Impairment of immune function in aquatic animals has been proposed as a possible consequence of low-level contamination of surface waters with anthropogenic substances such as through the discharge of wastewater into rivers, lakes, and oceans. The study at hand investigated the effects of chronic (32 weeks) exposure to sewage treatment plant (STP) effluent on the prevalence and distribution of different leucocyte populations in spleen samples of rainbow trout (Oncorhynchus mykiss). To simulate an infection, fish were injected intraperitoneally (ip) with inactivated Aeromonas salmonicida salmonicida, 6 weeks prior to the termination of the experiment.
View Article and Find Full Text PDF[The RICO rat (genetically hypercholesteremic): a good model for testing a food substance or a drug specific for a key enzyme of cholesterol metabolism].
Reprod Nutr Dev
October 1999
Laboratoire de Physiologie de la nutrition, unité associée, université Paris-Sud-XI/Inra, Orsay, France.
The genetically hypercholesterolemic RICO rat: a good model for testing a food substance or a drug specific for a key enzyme involved in cholesterol metabolism? The genetically hypercholesterolemic RICO rat, whose cholesterolemia is situated between 1.3 and 1.5 mg x mL(-1), possibly reaching 2 mg x mL(-1), after the addition of cholesterol to its food, possesses a different lipoprotein spectrum than man, because approximatively 70% of the plasma cholesterol is carried by HDL (28% of which are carried by the light HDL1 subfraction, rich in apolipoproteinE (apoE).
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