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Activation of autophagy with PF-06409577 alleviates heatstroke-induced organ injury.
Environ Int
January 2025
Fujian Provincial Key Laboratory of Transplant Biology, Fuzong Teaching Hospital (900th Hospital of Joint Logistic Support Force), Fujian University of Traditional Chinese Medicine, Fuzhou 350025, China; Laboratory of Basic Medicine, Fuzong Clinical Medical College of Fujian Medical University, Fuzhou 350025, China; Dongfang Hospital, Xiamen University, Fuzhou 350025, China; Organ Transplant Institute, 900th Hospital of Joint Logistic Support Force, Fuzhou 350025, China. Electronic address:
Heat waves are a significant environmental issue threatening global human health. Extreme temperatures can lead to various heat-related illnesses, with heatstroke being among the most severe. Currently, there are no effective treatments to mitigate the multi-organ damage caused by heatstroke.
View Article and Find Full Text PDFThe pathogenesis and management of heatstroke and heatstroke-induced lung injury.
Burns Trauma
January 2025
Treatment Center for Traumatic Injuries, The Third Affiliated Hospital, Southern Medical University, No. 183, Zhongshan Avenue West, Tianhe District, Guangzhou, 510063, Guangdong, China.
In the past two decades, record-breaking heat waves have caused an increasing number of heat-related deaths, including heatstroke, globally. Heatstroke is a life-threatening systemic condition characterized by a core body temperature >40°C and the subsequent development of multiple organ dysfunction syndrome. Lung injury is a well-documented complication of heatstroke and is usually the secondary cause of patient death.
View Article and Find Full Text PDFNomogram model for predicting secondary infection in critically ill patients with heatstroke: A pilot study from China.
PLoS One
December 2024
The First Clinical Medical College, Southern Medical University, Guangzhou, Guangdong, China.
Objective: In this retrospective analysis, we explored the clinical characteristics and risk factors of secondary infections in patients with severe heatstroke with the aim to gain epidemiological insights and identify risk factors for secondary infections.
Method: The study included 129 patients with severe heatstroke admitted to the General Hospital of the Southern Theater Command of the PLA between January 1, 2011, and December 31, 2021. Patients were divided into an infection group (n = 24) and a non-infection group (n = 105) based on infection occurrence within 48 h of intensive care unit (ICU) admission.
Characteristics of lower respiratory tract pathogens in critically ill patients with heatstroke: a retrospective multi-center study.
Front Cell Infect Microbiol
December 2024
Department of Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
This retrospective multicenter study was conducted across 83 intensive care units (ICUs) in 16 cities in Sichuan, China. Critically ill patients diagnosed with heatstroke and lung infections were included in the study. Specimens from the lower respiratory tract were collected for microbiological testing, and the characteristics of the pathogens were described.
View Article and Find Full Text PDFResveratrol inhibits ferroptosis in the lung tissues of heat stroke-induced rats via the Nrf2 pathway.
BMC Pharmacol Toxicol
November 2024
Department of Pulmonary and Critical Care Medicine, The 987th Hospital of Joint Logistics Support Force of Chinese PLA, Baoji, 721000, China.
Background: Heat stroke (HS) can lead to the development of pulmonary ferroptosis. The inhibition of pulmonary ferroptosis during HS improves patient prognosis. The aim of this study was to investigate the effects of resveratrol (RES) on heat stress at an ambient temperature of 42 °C.
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