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Estimation of PHA concentrations from cell density data in Cupriavidus necator.
Appl Microbiol Biotechnol
January 2025
Process Synthesis and Process Dynamics, Max Planck Institute for Dynamics of Complex Technical Systems, Magdeburg, Germany.
The production of biodegradable and biobased polymers is one way to overcome the present plastic pollution while using cheap and abundant feedstocks. Polyhydroxyalkanoates are a promising class of biopolymers that can be produced by various microorganisms. Within the production process, batch-to-batch variation occurs due to changing feedstock composition when using waste streams, slightly different starting conditions, or biological variance of the microorganisms.
View Article and Find Full Text PDFUnlocking Mechanisms for Soil Organic Matter Accumulation: Carbon Use Efficiency and Microbial Necromass as the Keys.
Glob Chang Biol
January 2025
Department of Renewable Resources, University of Alberta, Edmonton, Canada.
Soil microorganisms transform plant-derived C (carbon) into particulate organic C (POC) and mineral-associated C (MAOC) pools. While microbial carbon use efficiency (CUE) is widely recognized in current biogeochemical models as a key predictor of soil organic carbon (SOC) storage, large-scale empirical evidence is limited. In this study, we proposed and experimentally tested two predictors of POC and MAOC pool formation: microbial necromass (using amino sugars as a proxy) and CUE (by O-HO approach).
View Article and Find Full Text PDFGlut3 overexpression improves environmental glucose uptake and antitumor efficacy of CAR-T cells in solid tumors.
J Immunother Cancer
January 2025
Biotherapy Center & Cancer Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People's Republic of China
Background: Glucose deprivation inhibits T-cell metabolism and function. Glucose levels are low in the tumor microenvironment of solid tumors and insufficient glucose uptake limits the antitumor response of T cells. Furthermore, glucose restriction can contribute to the failure of chimeric antigen receptor T (CAR-T) cell therapy for solid tumors.
View Article and Find Full Text PDFStructural and functional modifications of quinoa protein via hyaluronic acid-induced Maillard reaction.
Int J Biol Macromol
January 2025
Key Laboratory of Coarse Cereal Processing, Ministry of Agriculture and Rural Affairs, Sichuan Engineering & Technology Research Center of Coarse Cereal Industrialization, School of Food and Biological Engineering, Chengdu University, Chengdu 610106, Sichuan, PR China; School of Basic Medicine, Chengdu University, Chengdu 610106, PR China. Electronic address:
In recent years, quinoa protein (QP) has attracted attention for its balanced amino acids composition, but its limited techno-functional properties continue to pose challenges for its utilization. Non-enzymatic Maillard glycation is considered as a promising strategy to expand the utilization of plant proteins in food processing due to its cost-effectiveness, spontaneous nature, and the lack of need for additives to initiate the reaction. Furthermore, the use of hyaluronic acid (HA) as an ingredient in food products is becoming increasingly accepted and popular.
View Article and Find Full Text PDFStrategies to reduce hyperglycemia-related anxiety in elite athletes with type 1 diabetes: A qualitative analysis.
PLoS One
January 2025
School of Human Nutrition, McGill University, Montreal, Québec, Canada.
Objective: Managing blood glucose levels is challenging for elite athletes with type 1 diabetes (T1D) as competition can cause unpredictable fluctuations. While fear of hypoglycemia during physical activity is well documented, research on hyperglycemia-related anxiety (HRA) is limited. HRA refers to the heightened fear that hyperglycemia-related symptoms will impair functioning.
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