The effect of a 2-week space mission on the geometry parameters of giant multipolar neurons of the brain stem reticular formation in the rats flown on board Cosmos-1887 and -2044 are studied. Compensation for a deficiency of vestibular informations from the trigeminal nerve system at the cost of an decreased length of the dendrites oriented toward primary sensory nucleus and from the vestibular system through an increase in the length of the vestibular sensory nuclei-oriented dendrites is discussed.
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Adv Sci (Weinh)
June 2024
Cancer Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China.
Polyploidization and depolyploidization are critical processes in the normal development and tissue homeostasis of diploid organisms. Recent investigations have revealed that polyaneuploid cancer cells (PACCs) exploit this ploidy variation as a survival strategy against anticancer treatment and for the repopulation of tumors. Unscheduled polyploidization and chromosomal instability in PACCs enhance malignancy and treatment resistance.
View Article and Find Full Text PDFPhys Rev Lett
November 2023
Ministry of Education Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter, Shaanxi Province Key Laboratory of Quantum Information and Quantum Optoelectronic Devices, School of Physics, Xi'an Jiaotong University, Xi'an 710049, China.
Traditional photonuclear reactions primarily excite giant dipole resonances, making the measurement of isovector giant resonances with higher multipolarities a great challenge. In this Letter, the manipulation of collective excitations of different multipole transitions in even-even nuclei via vortex γ photons is investigated. We develop the calculation method for photonuclear cross sections induced by the vortex γ photon beam using the fully self-consistent random-phase approximation plus particle-vibration coupling (RPA+PVC) model based on Skyrme density functional.
View Article and Find Full Text PDFEndoscopy
December 2023
Gastroenterology and Endoscopy Unit, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France.
Sci Adv
July 2023
Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
To understand the mechanism of acquired resistance to poly(ADP-ribose) polymerase inhibitors (PARPi) olaparib, we induced the formation of polyploid giant cancer cells (PGCCs) in ovarian and breast cancer cell lines, high-grade serous cancer (HGSC)-derived organoids, and patient-derived xenografts (PDXs). Time-lapse tracking of ovarian cancer cells revealed that PGCCs primarily developed from endoreplication after exposure to sublethal concentrations of olaparib. PGCCs exhibited features of senescent cells but, after olaparib withdrawal, can escape senescence via restitutional multipolar endomitosis and other noncanonical modes of cell division to generate mitotically competent resistant daughter cells.
View Article and Find Full Text PDFRSC Adv
July 2023
Innovative Technologies Laboratories (ITL), King Abdullah University of Science and Technology (KASUT) Saudi Arabia
Numerous applications of chiro-optical effects can be found in nanophotonics, including imaging and spin-selective absorption, particularly in sensing for separating and detecting chiral enantiomers. Flat single-layer metasurfaces composed of chiral or achiral sub-wavelength structures offer unique properties to manipulate the light due to their extraordinary light-matter interaction. However, at optical wavelengths, the generation of strong chirality is found to be challenging conventional chiral metasurface approaches.
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