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Background Doxorubicin is an important drug used in the treatment of children with acute leukemia, and cardiotoxicity is the most serious complication due to its use. The cardiac dysfunction due to doxorubicin can be acute, early, or late. Echocardiography is a non-invasive tool and can be employed to detect clinical and subclinical cardiac dysfunction and plan treatment strategies accordingly.
View Article and Find Full Text PDFDifferences in coronary microcirculation measurements during regadenoson vs. adenosine - induced hyperemia.
Cardiol J
December 2024
Department of Cardiology and Cardiovascular Interventions, University Hospital, Krakow, Poland.
Background: Little is known about the similarity of microcirculation assessment outcomes performed with regadenoson and adenosine. The aim of the current study was to compare coronary flow reserve (CFR) and index of microcirculatory resistance (IMR) assessment using adenosine and regadenoson, and to evaluate predictors regarding the size of differences.
Methods: 44 patients were enrolled and diagnosed between 2021 and 2023.
Deep ocular tumor classification model using cuckoo search algorithm and Caputo fractional gradient descent.
PeerJ Comput Sci
March 2024
College of Computer Science and Electronic Engineering, Hunan University, Changsha, Hunan, China.
While digital ocular fundus images are commonly used for diagnosing ocular tumors, interpreting these images poses challenges due to their complexity and the subtle features specific to tumors. Automated detection of ocular tumors is crucial for timely diagnosis and effective treatment. This study investigates a robust deep learning system designed for classifying ocular tumors.
View Article and Find Full Text PDFEffectiveness of benralizumab in the Tokyo Asthma Study (TOAST): A real-world prospective interventional trial.
Allergol Int
December 2024
Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan. Electronic address:
Background: Biologics are integral in the management of severe asthma. As the effectiveness of the anti-IL-5 receptor antibody benralizumab in Japan remains elusive, this study aimed to assess its real-world effectiveness in Japanese patients with severe asthma.
Methods: This prospective, interventional, single-arm clinical trial was conducted across ten facilities in Japan between September 2020 and July 2022.
Mathematical analysis with control of liver cirrhosis causing from HBV by taking early detection measures and chemotherapy treatment.
Sci Rep
November 2024
Mechatronics Department, Faculty of Engineering, University of Debrecen, Ótemető u. 4-5, Debrecen, 4028, Hungary.
Article Synopsis
- The study focuses on understanding how the HB virus causes harmful liver inflammation, aiming for early detection and treatment through corticosteroids or chemotherapy.
- The researchers have developed a new mathematical model to analyze the effects of the HB virus, emphasizing stability and reliability through various stability analyses.
- The research also explores control measures for preventing chronic HBV infections, using simulations to assess treatments in asymptomatic individuals within the community.
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