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Lymphomatoid papulosis type D: a newly described variant easily confused with cutaneous aggressive CD8-positive cytotoxic T-cell lymphoma.
Am J Dermatopathol
October 2012
Dermatopathology Department, St. John's Institute of Dermatology, London, UK.
Lymphomatoid papulosis (LyP) is defined as a chronic recurrent skin disease characterized by waxing and waning papules and nodules with histologic features of a CD30-positive T-cell lymphoma. Three histological subtypes (A, B, and C) were already recognized, and only more recently, a further variant simulating histologically an aggressive epidermotropic CD8-positive T-cell lymphoma was described, which was named LyP type D by the authors. We report the case of a 38-year-old woman presenting with a 1-year history of recurrent self-healing papules and nodules, predominantly affecting her upper and lower limbs but also the face, including the lower lip, with no associated systemic symptoms.
View Article and Find Full Text PDFDermoscopic Features of CD8-Positive Solitary Pagetoid Reticulosis on the Left Leg.
Dermatol Res Pract
July 2011
Department of Dermatology, Tokyo Women's Medical University, Medical Center East, 2-1-10 Nishi-Ogu, Arakawa-Ku, Tokyo 116-8567, Japan.
Solitary pagetoid reticulosis, also known as Woringer-Kolopp disease, is a rare subtype of cutaneous T-cell lymphoma. The typical clinical presentation is a solitary, localized psoriasiform or hyperkeratotic plaque or tumor located on the extremities. It primarily affects middle-aged males.
View Article and Find Full Text PDFEpidermotropic precursor T-cell lymphoma with highly aggressive clinical behavior simulating localized pagetoid reticulosis.
Am J Dermatopathol
August 2007
Department of Dermatology, Medical University of Graz, Austria.
We describe a 43-year-old patient with a solitary, eczematous plaque on his right nipple that had developed during the previous 6 weeks. Histopathology revealed a superficial band-like infiltrate of medium to large-sized pleomorphic lymphocytes with striking epidermotropism. The tumor cells expressed a T-phenotype (CD3+, CD20-) and were CD30-, CD4-, and CD8-negative.
View Article and Find Full Text PDFApproach to lymphoproliferative infiltrates of the skin. The difficult lesions.
Am J Clin Pathol
January 1999
Department of Dermatology, University Zurich, Switzerland.
Primary cutaneous lymphomas (CLs) are the second most common group of extranodal non-Hodgkin's lymphomas. Cutaneous T-cell lymphomas (CTCLs) account for 60% to 65% of all primary CLs, whereas 20% to 25% of CLs are of B-cell origin. Besides the most common and well-known forms of CL, such as mycosis fungoides and follicular B-cell lymphomas, there are some rare and unusual variants of CL that represent about 10% of lymphoproliferative skin infiltrates.
View Article and Find Full Text PDFA non-linear mathematical model for the in vivo evaluation of the RES phagocytic function.
Medinfo
April 1996
Dept. of Radiology, The Research Institute of Physico-Chemical Medicine, Moscow, Russia.
A new non-linear mathematical model was constructed in order to perform in vivo quantification of the RES phagocytic function. This method is based on the same technical facilities as used for the routine liver-spleen scintigraphy with radiocolloids [1, 2]. But kinetic modeling of dynamic Tc-99m-sulfur colloid data produced estimations of the functional RE-parameters: the clearance rate of the colloidal particles, the rate of phagocytosis, and the RES functional volume, which can not be obtained by classical approaches.
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