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New α-Glucosidase Inhibitors from Vietnamese Garcinia schomburgkiana Fruits.
Chem Biodivers
January 2025
Saigon University, Institute of Environment-Energy Technology, 273 An Duong Vuong Street, Ho Chi Minh City, Ho Chi Minh City, VIET NAM.
The chemical investigation of the fruits of Garcinia schomburgkiana growing in Vietnam led to the isolation of a new anofinic acid derivative, 5-hydroxy-8-methoxyanofinic acid (1), a new xanthone, xanthoschome C (2), and a known synthetic phenolic analogue, 4-(2-hydroxybenzyl)-2-(4-hydroxybenzyl) phenol (3), along with seven known xanthones (4-10). The structures of all isolated compounds were determined using spectroscopic techniques (NMR and MS), in conjunction with comparison to existing literature data. All isolated compounds were assessed for their α-glucosidase inhibitory activity and showed significant inhibition, with IC50 values ranging from 12.
View Article and Find Full Text PDFAnxiety and Depression Affect Sleep Quality: A Preliminary Investigation in Crowdsourced Samples of Autistic and Non-Autistic Adults.
J Autism Dev Disord
January 2025
Institutes for Behavior Resources, Inc, 2104 Maryland Ave., Baltimore, MD, 21218, USA.
We aimed to compare sleep problems in autistic and non-autistic adults with co-occurring depression and anxiety. The primary research question was whether autism status influences sleep quality, after accounting for the effects of depression and anxiety. We hypothesized that autistic adults would report higher levels of depression, anxiety, and sleep problems compared to non-autistic adults, after controlling for these covariates.
View Article and Find Full Text PDFCharacterization of a novel D-sorbitol dehydrogenase from Faunimonas pinastri A52C2.
Appl Microbiol Biotechnol
January 2025
Key Laboratory of Industrial Biotechnology, Ministry of Education, Jiangnan University, 1800 Lihu Avenue, Wuxi, 214122, China.
The enzyme D-sorbitol dehydrogenase (SLDH) facilitates the conversion of D-sorbitol to L-sorbose. While current knowledge of this enzyme class predominantly centers on Gluconobacter oxydans, the catalytic properties of enzymes from alternative sources, particularly their substrate specificity and coenzyme dependency, remain ambiguous. In this investigation, we conducted BLASTp analysis and screened out a novel SLDH (Fpsldh) from Faunimonas pinastri A52C2.
View Article and Find Full Text PDFParent-Adult Child Relationships and Repartnering After Gray Divorce.
J Gerontol B Psychol Sci Soc Sci
January 2025
Ryan White Center for Pediatric Infectious Diseases and Global Health, Indiana University School of Medicine. Indianapolis, Indiana, USA.
Objectives: The rise in gray divorce has catalyzed repartnering in later life. However, the antecedents of older adult repartnering remain poorly understood, particularly the potential role of adult children. A form of ambiguous loss, marital disruption often leads to family boundary ambiguity, thereby weakening family ties.
View Article and Find Full Text PDFShifting Lithium Amide Reactivity to the Radical Domain: Regioselective Radical C-H Functionalization of 3-Iodooxetane for the Synthesis of 1,5-Dioxaspiro[2.3]hexanes.
Angew Chem Int Ed Engl
January 2025
University of Bari: Universita degli Studi di Bari Aldo Moro, Dept. of Pharmacy - Drug Sciences, via E. Orabona 4, 70125, Bari, ITALY.
Strained spiro-heterocycles (SSH) have gained significant attention within the medicinal chemistry community as promising (sp3)-rich bioisosteres for their aromatic and non-spirocyclic counterparts. We herein report access to an unprecedented spiro-heterocycle - 1,5-dioxaspiro[2.3]hexane.
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