Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Activation of M1 muscarinic acetylcholine receptors by proline-rich oligopeptide 7a (
J Venom Anim Toxins Incl Trop Dis
February 2024
Center for Mathematics, Computation and Cognition (CMCC), Federal University of ABC, São Bernardo do Campo, SP, Brazil.
Background: The bioactive peptides derived from snake venoms of the Viperidae family species have been promising as therapeutic candidates for neuroprotection due to their ability to prevent neuronal cell loss, injury, and death. Therefore, this study aimed to evaluate the cytoprotective effects of a synthetic proline-rich oligopeptide 7a (PRO-7a;
Methods: Both cells were pre-treated for four hours with different concentrations of PRO-7a, submitted to HO-induced damage for 20 h, and then the oxidative stress markers were analyzed.
Comparison of fluoxetine and duloxetine hydrochloride therapeutic effects on patients with constipation-predominant irritable bowel syndrome.
Gastroenterol Hepatol Bed Bench
January 2022
Shahid Beheshti University of Medical Sciences, Department of Hematology and Blood Banking Tehran, Iran.
Aim: As few randomized clinical trials have verified the efficacy of selective and norepinephrine reuptake inhibitors in IBS, the current study made an inclusive comparison between them, and their effectiveness in IBS-C was proven.
Background: Irritable bowel syndrome with constipation (IBS-C) is a functional bowel disorder characterized by changes in bowel movements and abdominal pain in the absence of identifiable structural abnormalities. Despite much progress in the treatment of other types of IBS, limited treatments are available for IBS-C.
Formulation and Evaluation of Hydroxypropylmethylcellulose-dicyclomine Microsponges for Colon Targeted Drug Delivery: In Vitro and In Vivo Evaluation.
Curr Drug Deliv
May 2022
Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, 2014, Sakaka, Aliouf, Saudi Arabia.
Objective: The objective of the present study was to design novel colon targeted delivery of Dicyclomine Hydrochloride (DCH) microsponges.
Methods: Microsponges (MS1-MS4) based on different ratios of Hydroxypropylmethylcellulose (HPMC) and DCH were prepared by quasi-emulsion solvent diffusion method. Micro-sponges were analyzed by determining percent yield, encapsulation efficiency, drug content, drug-polymer compatibility and thermal stability.
Dietary modifications for infantile colic.
Cochrane Database Syst Rev
October 2018
School of Medicine, University of Central Lancashire, Preston, Lancashire, UK.
Background: Infantile colic is typically defined as full-force crying for at least three hours per day, on at least three days per week, for at least three weeks. This condition appears to be more frequent in the first six weeks of life (prevalence range of 17% to 25%), depending on the specific location reported and definitions used, and it usually resolves by three months of age. The aetiopathogenesis of infantile colic is unclear but most likely multifactorial.
View Article and Find Full Text PDFChemical cross-linking: A feasible approach to prolong doxylamine/pyridoxine release from spray-dried chitosan microspheres.
Eur J Pharm Sci
October 2018
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Medical University - Plovdiv, Bulgaria; High-technological Center for Emergency Medicine, Plovdiv, Bulgaria.
Spray-dried chitosan microparticles have been widely exploited as vehicles for mucosal drug delivery. Despite their advantages as pharmaceutical formulations, one of the major challenges is achieving sustained drug release, which would diminish toxicity and dosage frequency. The aim of this study was to formulate mucoadhesive glutaraldehyde cross-linked chitosan microparticles loaded with doxylamine succinate and pyridoxine hydrochloride as potential nasal drug delivery systems with sustained release.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!