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Understanding the Myelin Ratio from First Principles, Its Derivation, Uses and Artifacts.
ASN Neuro
January 2025
Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI, USA.
In light of the increasing importance for measuring myelin ratios - the ratio of axon-to-fiber (axon + myelin) diameters in myelin internodes - to understand normal physiology, disease states, repair mechanisms and myelin plasticity, there is urgent need to minimize processing and statistical artifacts in current methodologies. Many contemporary studies fall prey to a variety of artifacts, reducing study outcome robustness and slowing development of novel therapeutics. Underlying causes stem from a lack of understanding of the myelin ratio, which has persisted more than a century.
View Article and Find Full Text PDFWearable Sensors for Plants: Status and Prospects.
Biosensors (Basel)
January 2025
College of Engineering, Huazhong Agricultural University, Wuhan 430070, China.
The increasing demand for smart agriculture has led to the development of agricultural sensor technology. Wearable sensors show great potential for monitoring the physiological and surrounding environmental information for plants due to their high flexibility, biocompatibility, and scalability. However, wearable sensors for plants face several challenges that hinder their large-scale practical application.
View Article and Find Full Text PDFThe dysfunction of mitochondria, the primary source of cellular energy and producer of reactive oxygen species (ROS), is associated with brain aging and neurodegenerative diseases. Scientific evidence indicates that light in the visible and near-infrared spectrum can modulate mitochondrial activity, a phenomenon known in medicine as photobiomodulation therapy (PBM-t). The beneficial effects of PBM-t on dementia and neurodegeneration have been reviewed in the literature.
View Article and Find Full Text PDFMyofascial System and Physical Exercise: A Narrative Review on Stiffening (Part II).
Cureus
December 2024
Rehabilitation Medicine, Spine Center, Bologna, ITA.
In the past two decades, interest in the fascial system has exponentially increased, particularly manual treatment and stretching exercises. The fascia's fundamental role remains the transmission of tensions, although this function can be impaired due to excessive or reduced stiffness. This second part of the work outlines the basic principles concerning the importance of appropriate and balanced fascial stiffness for correct postural and functional maintenance of the human body.
View Article and Find Full Text PDFCross-species comparisons between pigs and mice reveal conserved sex-specific intraspinal inflammatory responses after spinal cord injury.
J Neuroinflammation
January 2025
Spinal Cord and Brain Injury Research Center, Department of Physiology, College of Medicine, University of Kentucky, Lexington Kentucky, USA.
Objective: Therapeutic translation is challenging in spinal cord injury (SCI) and large animal models with high clinical relevance may accelerate therapeutic development. Pigs have important anatomical and physiological similarities to humans. Intraspinal inflammation mediates SCI pathophysiology.
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