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Previous short-term disuse dictates muscle gene expression and physiological adaptations to subsequent resistance exercise.
J Physiol
January 2025
Department of Biomedical Sciences, University of Padova, Padova, Italy.
Short-term unloading experienced following injury or hospitalisation induces muscle atrophy and weakness. The effects of exercise following unloading have been scarcely investigated. We investigated the functional and molecular adaptations to a resistance training (RT) programme following short-term unloading.
View Article and Find Full Text PDFDifferences in protein lactylation between pale, soft and exudative and red, firm and non-exudative pork.
Meat Sci
March 2025
State Key Laboratory of Meat Quality Control and Cultured Meat Development, Ministry of Education China, Jiangsu Collaborative Innovation Center of Meat Production and Processing, Quality and Safety Control, College of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
This study aimed to understand the development of pale, soft, and exudative (PSE) pork from a new perspective by comparing the differences of lactate-induced protein lactylation and its potential regulators including E1A binding protein p300 (p300) and cAMP response element binding protein (CBP) between PSE and red, firm, and non-exudative (RFN) pork at 1 h postmortem. Results demonstrated that PSE pork presented lower glycogen contents and higher lactate levels than RFN pork (P < 0.05).
View Article and Find Full Text PDFIn vivo imaging of glycogen in human muscle.
Nat Commun
December 2024
Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, China.
Probing regional glycogen metabolism in humans non-invasively has been challenging due to a lack of sensitive approaches. Here we studied human muscle glycogen dynamics post-exercise with a spatial resolution of millimeters and temporal resolution of minutes, using relayed nuclear Overhauser effect (glycoNOE) MRI. Data at 5T showed a homogeneous distribution of glycogen in resting muscle, with an average concentration of 99 ± 13 mM.
View Article and Find Full Text PDFOptimized MALDI2-Mass Spectrometry Imaging for Stable Isotope Tracing of Tissue-Specific Metabolic Pathways in Mice.
Anal Chem
January 2025
State Key Laboratory of Environmental and Biological Analysis, Hong Kong Baptist University, Hong Kong SAR 999077, China.
Spatial stable isotope tracing metabolic imaging is a cutting-edge technique designed to investigate tissue-specific metabolic functions and heterogeneity. Traditional matrix-assisted laser desorption ionization-mass spectrometry imaging (MALDI-MSI) techniques often struggle with low coverage of low-molecular-weight (LMW) metabolites, which are often crucial for spatial metabolic studies. To address this, we developed a high-coverage spatial isotope tracing metabolic method that incorporates optimized matrix selection, sample preparation protocols, and enhanced post-ionization (MALDI2) techniques.
View Article and Find Full Text PDFThe Implications of the Non-precipitable Nature of Branched Amylose with Concanavalin A for the Branched Structures of Rice Amylose.
J Appl Glycosci (1999)
November 2024
1 Department of Food Science and Biotechnology, Kagoshima University.
The branched structure of amylose was probed using concanavalin A (ConA) lectin, which forms precipitable aggregates with highly branched glucans, such as glycogen and amylopectin. Rice (japonica cultivar) amylose was fractionated from de-fatted, gelatinized starch by precipitation with 1-butanol (BuOH) and purified by ultracentrifugation and repeated crystallization. The purified amylose still has short side chains, whose chain-length (CL) distribution resembles that of amylopectin.
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