The effect of treatment of severe respiratory distress syndrome with a natural porcine surfactant (Curosurf) on the radiographic appearances and degree of aeration is described. Separate assessment of each lung of 22 preterm babies was made before and after surfactant administration. The beneficial effect of Curosurf treatment on the aeration of the lungs was seen in 19 (86%) of the babies.
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Rev Gastroenterol Peru
January 2025
Department of Gastroenterology and Endoscopy, Colombia University Clinic, Bogotá, Colombia.
Objective: This review aims to evaluate the efficacy and safety of premedication comprising mucolytics and/or defoaming agents to improve the quality of visualization during elective upper digestive endoscopy (elective upper GI endoscopy) procedure.
Materials And Methods: A systematic review of the literature contained in electronic databases (Medline/Pubmed, Embase, and Lilacs) was performed to identify randomized controlled trials and systematic reviews that assessed patients undergoing upper gastrointestinal endoscopy (elective upper GI Endoscopy) under sedation, after being premedicated with mucolytics and/or defoaming agents for mucous clearance. A meta-analysis was conducted to determine the relative efficacy and safety profile of such premedication.
AAPS J
January 2025
Institute of Drug Metabolism and Pharmaceutical Analysis, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.
Freeze drying is one of the common methods to extend the long-term stability of biologicals. Biological products in solid form have the advantages of convenient transportation and stable long-term storage. However, long reconstitution time and extensive visible bubbles are frequently generated during the reconstitution process for many freeze-dried protein formulations, which can potentially affect the management efficiency of staff, patient compliance, and product quality.
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January 2025
Department of Chemistry, Center for Physical and Mathematical Sciences, Federal University of Santa Catarina, Florianópolis, SC, 88040-900, Brazil.
Developing orally administered pediatric formulations presents significant challenges due to the unique characteristics of pediatric patients. Terbinafine hydrochloride (TER), a powerful antifungal agent, is effective against various fungal infections, including Tinea capitis, which is common in children. However, its low aqueous solubility necessitates innovative pharmaceutical strategies to enhance its effectiveness.
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January 2025
Department of Mechanical and Nuclear Engineering, Virginia Commonwealth University, Richmond, VA, United States of America.
The administration of surfactant aerosol therapy to preterm infants receiving continuous positive airway pressure (CPAP) respiratory support is highly challenging due to small flow passages, relatively high ventilation flow rates, rapid breathing and small inhalation volumes. To overcome these challenges, the objective of this study was to implement a validated computational fluid dynamics (CFD) model and develop an overlay nasal prong interface design for use with CPAP respiratory support that enables high efficiency powder aerosol delivery to the lungs of preterm infants when needed (i.e.
View Article and Find Full Text PDFCrit Rev Ther Drug Carrier Syst
January 2025
Associate Professor of Pharmaceutics, Faculty of Health and Allied Sciences, Amity University Noida India, Pharmaceutics Domain, Uttar Pradesh, India; Member, Indian National Young Academy of Sciences (INYAS), INSA, New Delhi, India.
Microemulsions (MEs) are homogeneous, isotropic, transparent, and thermodynamically stable mixtures of water, oil, and surfactants. Their unique properties have garnered increasing interest across various fields, including chemistry, pharmacology, biotechnology, and biology. This review aims to provide a comprehensive overview of ME compositions, their macroscopic appearances, and the roles of their essential components - oil, water, surfactant, and co-surfactant - in controlling the nature and stability of MEs.
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