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L. Leaf Extract Dose-Dependently Modulates Oxidative Stress in the Kidney and Exerts Anti-Fibrotic and Anti-Inflammatory Properties by the Molecular Mechanisms Independent of NRF-2 Signalization Mirroring the Effects of Losartan in SHR.
Int J Mol Sci
December 2024
Department for Cardiovascular Physiology, Institute for Medical Research, National Institute of Republic of Serbia, University of Belgrade, Dr Subotića 4, P.O. Box 39, 11129 Belgrade, Serbia.
Previously, we confirmed systemic antihypertensive and antioxidant properties of L. leaf extract (UE) in spontaneously hypertensive rats (SHR). Here, we aimed to evaluate whether UE can alter the NO and Nrf-2 signaling to prevent local oxidative stress and kidney damage in the model of essential hypertension.
View Article and Find Full Text PDFEndothelial cell-selective adhesion molecule deficiency exhibits increased pulmonary vascular resistance due to impaired endothelial nitric oxide signaling.
Am J Physiol Heart Circ Physiol
February 2025
Department of Physiology, Medical College of Georgia, Augusta University, Augusta, Georgia, United States.
Endothelial cell-selective adhesion molecule (ESAM) is a member of tight junction molecules, highly abundant in the heart and the lung, and plays a role in regulating endothelial cell permeability. We previously reported that mice with genetic ESAM deficiency () exhibit coronary microvascular dysfunction leading to the development of left ventricular diastolic dysfunction. Here, we hypothesize that mice display impairments in the pulmonary vasculature, affecting the overall pulmonary vascular resistance (PVR).
View Article and Find Full Text PDFAntitumoral action of carvedilol-a repositioning study of the drug incorporated into mesoporous silica MCM-41.
Nanotechnology
November 2024
University of Franca; Av. Dr. Armando Salles Oliveira, 201, Pq. Universitário CEP 14404-600, Franca, SP, Brazil.
We have studied repositioning of carvedilol (an antihypertensive drug) incorporated into MCM-41 mesoporous silica. The repositioning proposes a reduction in the slow pace of discovery of new drugs, as well as toxicological safety and a significant reduction in high research costs, making it an attractive strategy for researchers and large pharmaceutical companies. We obtained MCM-41 bysynthesis and functionalized it by post-synthesis grafting with aminopropyltriethoxysilane (APTES) only or with folic acid (FA), which gave MCM-41-APTES and MCM-41-APTES-FA, respectively.
View Article and Find Full Text PDFUnveiling detoxifying symbiosis and dietary influence on the Southern green shield bug microbiota.
FEMS Microbiol Ecol
November 2024
Department of Microbiology, Radboud Institute for Biological and Environmental Sciences (RIBES), Radboud University, PO Box 9010, 6500 GL Nijmegen, The Netherlands.
Article Synopsis
- The Southern green shield bug, Nezara viridula, is an invasive pest that threatens crops and global food security due to its feeding habits.
- This study investigates how the bug's microbial community helps it detoxify the harmful plant metabolite 3-nitropropionic acid (NPA), finding that six out of eight strains can detoxify this toxin.
- Additionally, it examines how diet affects the gut microbes of N. viridula, revealing that a single-plant diet changes microbial composition and that core microbes support each other while inhibiting transient ones, enhancing the bug's resilience to plant defenses.
Proanthocyanidins protects 3-NPA-induced ovarian function decline by activating SESTRIN2-NRF2-mediated oxidative stress in mice.
Sci Rep
October 2024
School of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang, 330031, Jiangxi, China.
Abnormal apoptosis of ovarian cells caused by oxidative stress is an important cause of premature ovarian failure (POF). Previous studies revealed that proanthocyanidins (PCs) are powerful natural antioxidants that can safely prevent oxidative damage in humans. However, the protective effect and mechanism of PCs on ovarian function during the course of POF remain unknown.
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