In Alzheimer's disease, all ganglio-series gangliosides (GM1, GD1a, GD1b and GT1b) were found to be decreased in temporal and frontal cortex, and nucleus basalis of Meynert. In addition, in Alzheimer's disease simple gangliosides (GM2, GM3) were elevated in frontal and parietal cortex, possibly correlating to accelerated lysosomal degradation of gangliosides and/or astrogliosis occurring during neuronal death.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/0197-0186(92)90058-y | DOI Listing |
Publication Analysis
Top Keywords
alzheimer's disease
12
cortical distribution
4
gangliosides
4
distribution gangliosides
4
gangliosides alzheimer's
4
disease alzheimer's
4
disease ganglio-series
4
ganglio-series gangliosides
4
gangliosides gm1
4
gm1 gd1a
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!