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Clinical Performance and Safety of Cerviron® Vaginal Ovules in the Management of Symptomatic Cervical Lesions: A National, Multicentric Study.
Curr Ther Res Clin Exp
October 2024
Department of General and Dental Medical Radiology and Imaging, "Victor Babes" University of Medicine and Pharmacy Timisoara, Timisoara, Romania.
Background: Cervical ectropion is frequently associated with vaginal symptoms requiring therapeutic intervention. However, no scientific consensus has been reached regarding the use of local re-epithelialization therapy to prevent severe bleeding, wound inflammation, and infection of cervical lesions.
Objective: The aim of our study was to investigate the aspect of the cervix by colposcopy after a 3-month treatment with an intravaginal medical device in the context of postoperative care of the symptomatic ectropion.
A randomized double-blind noninferiority clinical multicenter trial on oral moxifloxacin versus placebo in the outpatient treatment of uncomplicated acute appendicitis: APPAC IV study protocol.
Scand J Surg
December 2024
Division of Digestive Surgery and Urology Turku University Hospital P.O. Box 52 20521 Turku Finland.
Background: Antibiotic therapy is currently considered a safe and effective treatment alternative for computed tomography (CT)-confirmed uncomplicated acute appendicitis with recent studies reporting good results on both oral antibiotics only and outpatient management. Furthermore, there are promising pilot results on uncomplicated acute appendicitis management with symptomatic treatment (placebo). This trial aims to assess whether both antibiotics and hospitalization can be safely omitted from the treatment of uncomplicated acute appendicitis.
View Article and Find Full Text PDFBiofilm growth dynamics in a micro-irrigation with reclaimed wastewater in the field scale.
J Environ Manage
November 2024
INRAE, UMR G-EAU, University of Montpellier, Montpellier, France. Electronic address:
The dripper clogging due to the development of biofilm can reduce the benefits of micro-irrigation technology implementation using reclaimed wastewater. The narrow cross-section and labyrinth geometry of the dripper channel enhance the fouling mechanisms. The aim of this study was to evaluate the water distribution and biofouling of drip irrigation systems at the field scale during irrigation with treated wastewater.
View Article and Find Full Text PDFImpact of an appendicolith and its characteristics on the severity of acute appendicitis.
BJS Open
September 2024
Division of Digestive Surgery and Urology, Turku University Hospital, Turku, Finland.
Article Synopsis
- Antibiotics can effectively treat uncomplicated acute appendicitis without an appendicolith, but this study focuses on how the presence and characteristics of an appendicolith (a small calculus in the appendix) relate to the severity of appendicitis.
- In a review of over 3,000 patients with suspected appendicitis, it was found that those with an appendicolith had a significantly higher rate of complications (47.1% vs. 21.5%) compared to those without.
- Key findings indicated that certain features of the appendicolith, such as its size, location, and associated appendiceal wall changes, are linked to an increased risk of serious complications in appendicitis patients.
Parastomal Hernia Prevention Using Funnel-Shaped Intra-Abdominal Mesh Compared to No Mesh: The Chimney Randomized Clinical Trial.
JAMA Surg
November 2024
Oulu University Hospital, Medical Research Center Oulu, Oulu, Finland.
Article Synopsis
- The study examines the effectiveness and safety of funnel-shaped synthetic mesh in preventing parastomal hernias among patients undergoing surgery for rectal adenocarcinoma.
- Conducted as a randomized trial across multiple hospitals in Finland and Sweden, it involved 143 patients, with a focus on comparing outcomes between those receiving the mesh and those who did not.
- Results revealed a significant reduction in the incidence of parastomal hernias at 12 months: 10% in the mesh group versus 37% in the control group, indicating the mesh's potential benefit in hernia prevention.
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