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Primary Epithelioid Angiosarcoma of the Penis: A Case Report With a Brief Review of the Literature.
Am J Dermatopathol
February 2025
Clinic of Dermatology, IRCCS San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy.
Angiosarcoma of the penis is an exceptionally rare mesenchymal tumor, with only about 30 cases documented in the literature. Because of its rarity and the often nonspecific clinical presentation, histopathological examination plays a critical role in accurate diagnosis. Angiosarcoma of the penis typically arises in the corpus cavernosum but has also been reported in the glans and urethra, often presenting with metastases.
View Article and Find Full Text PDFTargetoid hemosiderotic hemangioma: A review article.
Semin Diagn Pathol
November 2024
University of Mississippi Medical Center, 2500 N State St, Jackson, MS 39216, United States. Electronic address:
Article Synopsis
- Targetoid hemosiderotic hemangioma (THH) is a rare vascular lesion that mainly affects adults, usually developing after trauma, with no significant gender preference.
- The review analyzes THH's characteristics, differentiating it from similar conditions like Kaposi's sarcoma and retiform hemangioendothelioma.
- Clinically, THH appears as painless lesions with a distinctive target-like look; histologically, it shows specific vascular features and can be identified with immunohistochemical markers.
Pseudomyogenic hemangioendothelioma presenting as a penile lesion.
Virchows Arch
December 2024
Department of Pathology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Pseudomyogenic hemangioendothelioma (PHE) is a rare, usually multifocal neoplasm typically affecting individuals in the second-to-fourth decade of life, with a male predominance. It often arises in the distal extremities and characteristically involves multiple tissue planes. Presentation of this neoplasm as a primary penile lesion is exceedingly rare, with only five cases previously documented in the literature.
View Article and Find Full Text PDFRole of the Hippo-YAP/TAZ Pathway in Epithelioid Hemangioendothelioma and its Potential as a Therapeutic Target.
Anticancer Res
October 2024
Department of Medical Oncology, Hyogo Cancer Center, Hyogo, Japan
Article Synopsis
- Epithelioid hemangioendothelioma (EHE) is a rare malignant tumor that originates from vascular endothelial cells, with a focus on the Hippo-YAP/TAZ signaling pathway influencing its development.
- Genetic alterations in EHE are often characterized by specific fusions, primarily TAZ-CAMTA1 and YAP-TFE3, which contribute to its oncogenic behavior and impact prognosis.
- The study highlights recent findings on the Hippo-YAP/TAZ pathway, emphasizing its potential as a therapeutic target for developing new treatments for EHE.
Subclavian vein epithelioid hemangioendothelioma: Multidisciplinary surgical approach.
J Vasc Surg Cases Innov Tech
June 2024
Department of Vascular Surgery, Royal Infirmary Edinburgh, Edinburgh, Scotland, UK.
Epithelioid hemangioendothelioma (EHE) is a rare primary vascular tumour, usually malignant. We present the case of a 60-year-old woman who presented with hoarseness of voice and a persistent cough. During evaluation, a left supraclavicular mass was discovered.
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