The BB rat is among the best models of insulin-dependent diabetes mellitus--with onset and pathogenesis closely resembling the human disease. One unusual feature is a severe T-cell lymphopenia, which appears to be inherited as a recessive trait controlled by a single gene, Lyp. Based on genetic analysis of several crosses, we show that development of diabetes involves at least three genes: Lyp, which is tightly linked to the neuropeptide Y (Npy) gene on chromosome 4, a gene linked to the major histocompatibility complex (MHC) on chromosome 20, and a third unmapped gene for which the Fischer rat strain carries an allele conferring resistance.

Download full-text PDF

Source
http://dx.doi.org/10.1038/ng0992-56DOI Listing

Publication Analysis

Top Keywords

genetic dissection
4
dissection autoimmune
4
autoimmune type
4
type diabetes
4
diabetes rat
4
rat rat
4
rat best
4
best models
4
models insulin-dependent
4
insulin-dependent diabetes
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!