Neuronal activity of the ventromedial hypothalamus was studied in food- and water-deprived, saturated unrestrained rats and after i. p. administrations of alcohol, nembutal, 5-HT and disulphiram. The neurons whose activity did not depend on motivational states decreased their firing rate. The data obtained suggests that motivational and emotional effects of the ventromedial hypothalamus are based on various cell mechanisms.

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