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Ciliary ganglioplegic migraine: migraine-related prolonged mydriasis.
Cephalalgia
February 2011
Department of Neurology, University Hospital Fundación Hospital Alcorcón, Avda. Budapest 1, Alcorcón, Madrid, Spain.
Background: Transient, unilateral mydriasis has been reported in migraine patients, and this has been regarded as a possible co-morbidity between migraine and Adie's tonic pupil. Mydriasis that outlasts the duration of migraine attacks is rare.
Methods: Through an eight-year period we have studied all patients referred to our neurological clinic because of migraine attack with mydriasis.
[Male contraception].
Minerva Ginecol
October 2004
Unità di Andrologia, Azienda Ospedaliera San Paolo, Polo Universitario, Milan, Italy.
The only safe method of male contraception is vasectomy, with high reversibility secured by microsurgery. Italy, however, suffers from a lack of regulations on this subject. Hormonal treatment (testosterone plus progestational hormones) is far from providing reliability and safety, while some perspectives, theoretical only for the time being, are offered by studies on functional infertility induced by either speeding up (ganglioplegic, sympathomimetic, parasympatholytic, oxytocin, endothelin, angiotensin) or inhibiting (sympatholytic) the sperm transport through the epididymis, or altering the epididymal environment (alpha-chloridin, chlorodeoxyglucose).
View Article and Find Full Text PDFPressor effects of electrical stimulation of medial prefrontal cortex in unanesthetized rats.
J Neurosci Res
August 2004
Department of Pharmacology, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
The medial prefrontal cortex (MPFC) is involved in central nervous system (CNS)-mediated cardiovascular modulation. We compared the cardiovascular effects of electrical stimulation (EE) of the MPFC in unanesthetized rats to those observed after stimulation of the same area in urethane-anesthetized rats. Electrical stimulation (35, 106, 177, 247, 318, and 389 microA rms/10 sec, 60-Hz sine wave) of the MPFC of urethane-anesthetized rats caused depressor responses of stimulus-related intensity.
View Article and Find Full Text PDF4-Oxystilbene compounds are selective ligands for neuronal nicotinic alphaBungarotoxin receptors.
Br J Pharmacol
July 1998
CNR Cellular and Molecular Pharmacology Center, Department of Medical Pharmacology, University of Milan, Italy.
1. Starting from the structure of an old 4-oxystilbene derivate with ganglioplegic activity (MG624), we synthesized two further derivates (F2 and F3) and two stereoisomers of F3 (F3A and F3B), and studied their selective effect on neuronal nicotinic acetylcholine receptor (AChR) subtypes. 2.
View Article and Find Full Text PDFFrom alpha and beta to I1: an overview of sympathetic receptors involved in blood pressure control targets for drug treatment.
J Cardiovasc Pharmacol
January 1997
Department of Pharmacotherapy, Academic Medical Center, University of Amsterdam, The Netherlands.
There is no doubt that the sympathetic nervous system (SNS) plays an important role in the pathogenesis and maintenance of hypertensive disease, although many details concerning this association remain to be clarified. Over the years, several types of antihypertensive drugs have been developed that can impair SNS activity at virtually all levels of the system. Alpha and beta-adrenoceptor antagonists, postganglionic sympathetic neuron blockers and ganglioplegic agents are well-known examples of drugs with a predominantly peripheral activity.
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