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Protocol for inducing beige adipocytes in white adipose tissue of mouse using cold exposure and CL316,243 injection.
STAR Protoc
January 2025
School of Biomedical Sciences, Heart and Vascular Institute, The Chinese University of Hong Kong, Hong Kong SAR, China. Electronic address:
White adipose tissue (WAT) beiging holds significant therapeutic potential for combating obesity. Here, we present a protocol for inducing beige WAT in mice using both cold exposure and CL316,243 treatment. We describe steps for intraperitoneal injection, and subcutaneous WAT (sWAT) isolation, dissection, and fixation.
View Article and Find Full Text PDFThe efficacy and safety of thymosin α1 for sepsis (TESTS): multicentre, double blinded, randomised, placebo controlled, phase 3 trial.
BMJ
January 2025
Department of Critical Care Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong province, China
Objective: To evaluate whether the immunomodulatory drug thymosin α1 reduces mortality in adults with sepsis.
Design: Multicentre, double blinded, placebo controlled phase 3 trial.
Setting: 22 centres in China, September 2016 to December 2020.
Case of Life-threating Asthma Exacerbation Successfully Treated with Benralizumab.
Intern Med
January 2025
Department of Respiratory Medicine, NHO Okayama Medical Center, Japan.
A 52-year-old Japanese man with a history of childhood asthma presented at our emergency department with progressive dyspnea. Despite subcutaneous adrenaline injections, salbutamol nebulization, and intravenous methylprednisolone, the carbon dioxide partial pressure (pCO) increased to 110 mmHg. The patient was intubated, and mechanical ventilation was initiated because of severe respiratory failure.
View Article and Find Full Text PDFAn Exploratory Study of PN HPT for Treating Postsurgical Atrophic and Depressed Scars.
J Cosmet Dermatol
January 2025
Clinical Pharmacology Consultant in Aesthetic Medicine, Milan, Italy.
Background: Postsurgical atrophic scars tend to respond poorly to treatments, especially non-energy-based ones. Hydrophilic PN HPT (Polynucleotides High Purification Technology) injected intradermally is a non-energy-based option with an immediate volume-enhancing effect that indirectly improves the fibroblast synthesis of collagen and extracellular matrix. The PN HPT ingredient has the further benefit of a dermal "priming" effect that enhances the efficacy of other scar treatments.
View Article and Find Full Text PDFComparison of Mesotherapy and Transcutaneous Electrical Nerve Stimulation (TENS) in the Management of Chronic Non-Specific Low Back Pain: A Randomized Clinical Trial.
Tunis Med
January 2025
Physical Medicine and rehabilitation Department, Military hospital of Tunis, Tunisia.
Unlabelled: Introduction-Aim: Chronic low back pain affects 80% of individuals at some point in their lives and has significant socioeconomic impacts. This study aims to compare the efficacy of mesotherapy with transcutaneous electrical nerve stimulation (TENS) in treating chronic low back pain.
Methods: A randomized bicentric study was conducted at the Military Hospital of Tunis and the Multidisciplinary Military Polyclinic of Mefeteh Saadallah between August 2023 and June 2024.
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