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Screening and Genomic Profiling of Antimicrobial Bacteria Sourced from Poultry Slaughterhouse Effluents: Bacteriocin Production and Safety Evaluation.
Genes (Basel)
December 2024
Departamento de Nutrición y Ciencia de los Alimentos (NUTRYCIAL), Sección Departamental de Nutrición y Ciencia de los Alimentos (SD-NUTRYCIAL), Facultad de Veterinaria, Universidad Complutense de Madrid (UCM), Avenida Puerta de Hierro, s/n, 28040 Madrid, Spain.
Antimicrobial-resistant (AMR) pathogens represent a serious threat to public health, particularly in food production systems where antibiotic use remains widespread. As a result, alternative antimicrobial treatments to antibiotics are essential for effectively managing bacterial infections. This study aimed to identify and characterize novel antimicrobial peptides produced by bacteria, known as bacteriocins, as well as to recognize safe bacteriocin-producing strains, sourced from poultry slaughterhouse effluents.
View Article and Find Full Text PDFMulti-conflict islands are a widespread trend within Serratia spp.
Cell Rep
December 2024
Department of Microbial Sciences, School of Biosciences, University of Surrey, Guildford, Surrey, UK. Electronic address:
Bacteria carry numerous anti-phage systems in "defense islands" or hotspots. Recent studies have delineated the content and boundaries of these islands in various species, revealing instances of islands that encode additional factors, including antibiotic resistance genes, stress genes, type VI secretion system (T6SS)-dependent effectors, and virulence factors. Our study identifies three defense islands in the Serratia genus with a mixed cargo of anti-phage systems, virulence factors, and different types of anti-bacterial modules, revealing a widespread trend of co-accumulation that extends beyond T6SS-dependent effectors to colicins and contact-dependent inhibition systems.
View Article and Find Full Text PDFDiscovering the Bioactive Compounds Binding to α-Adrenergic Receptor in Guizhi Fuling Formula and Revealing Their Interactions by Immobilizing the Receptor Through Colicin L7 DNase/Immunity Protein 7 Ultra-Affinity System.
J Sep Sci
December 2024
Engineering Research Center of Tibetan Medicine Detection Technology, Ministry of Education, Xizang Minzu University, Xianyang, P. R. China.
Article Synopsis
- The study investigates Guizhi Fuling Formula (GFF) and α-adrenergic receptors (α-AR) using a novel method involving Colicin L7 DNase (CL7) and its immune protein (Im7) for immobilizing α-AR to a column.
- The immobilization resulted in a stable α-AR column, facilitating the screening of active compounds in GFF, leading to the identification of paeoniflorin, cinnamic acid, and paeonol.
- Notably, cinnamic acid and paeonol bind to the same site on α-AR as the drug tamsulosin, demonstrating the potential of this method for rapid analysis of functional compounds from
The strength of interspecies interaction in a microbial community determines its susceptibility to invasion.
PLoS Biol
November 2024
Dept. of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.
Previous work shows that a host's resident microbial community can provide resistance against an invading pathogen. However, this community is continuously changing over time due to adaptive mutations, and how these changes affect the invasion resistance of these communities remains poorly understood. To address this knowledge gap, we used an experimental evolution approach in synthetic communities of Escherichia coli and Salmonella Typhimurium to investigate how the invasion resistance of this community against a bacterium expressing a virulent phenotype, i.
View Article and Find Full Text PDFWhole-Genome Sequencing And Characterization Of Two Bacillus velezensis Strains from Termitarium and A Comprehensive Comparative Genomic Analysis of Biosynthetic Gene Clusters.
Curr Microbiol
November 2024
Department of Genetics, School of Biological Sciences, Madurai Kamaraj University, Madurai, 625021, India.
The species Bacillus velezensis is known for its biosynthetic potential and metabolic versatility in producing several secondary metabolites and promoting plant growth. In this study, we isolated two B. velezensis strains, WGTg-8 and WGTm-299, from the termite gut and termitarium, which exhibited antimicrobial activity against multiple clinical and phytopathogens.
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