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The efficacy of diltiazem, glyceryl trinitrate, nifedipine, minoxidil, and lidocaine for the medical management of anal fissure: a systematic review and network meta-analysis of randomized controlled trials.
Int J Surg
January 2025
The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, China.
Purpose: Anal fissure (AF) is a common anorectal condition causing pain, bleeding, and other perianal discomfort. This study conducts a network meta-analysis to compare the efficacy and side effect profiles of pharmacological treatments for AF, including diltiazem, glyceryl trinitrate, nifedipine, minoxidil, and Lidocaine.
Methods: Following PRISMA guidelines, a systematic review and network meta-analysis were performed.
Towards contrast-agnostic soft segmentation of the spinal cord.
Med Image Anal
January 2025
NeuroPoly Lab, Institute of Biomedical Engineering, Polytechnique Montréal, Montréal, Québec, Canada; Mila - Québec Artificial Intelligence Institute, Montréal, Québec, Canada; Functional Neuroimaging Unit, CRIUGM, University of Montreal, Montreal, Québec, Canada; Centre de recherche du CHU Sainte-Justine, Université de Montréal, Montréal, Québec, Canada. Electronic address:
Spinal cord segmentation is clinically relevant and is notably used to compute spinal cord cross-sectional area (CSA) for the diagnosis and monitoring of cord compression or neurodegenerative diseases such as multiple sclerosis. While several semi and automatic methods exist, one key limitation remains: the segmentation depends on the MRI contrast, resulting in different CSA across contrasts. This is partly due to the varying appearance of the boundary between the spinal cord and the cerebrospinal fluid that depends on the sequence and acquisition parameters.
View Article and Find Full Text PDFClinical observation on prognosis of mixed hemorrhoids treated with polidocanol injection combined with automatic elastic thread ligation operation.
World J Gastrointest Surg
January 2025
Department Market Operations, Pingxiang People's Hospital, Pingxiang 337000, Jiangxi Province, China.
Background: A total of 100 patients diagnosed with mixed hemorrhoids from October 2022 to September 2023 in our hospital were randomly divided into groups by dice rolling and compared with the efficacy of different treatment options.
Aim: To analyze the clinical effect and prognosis of mixed hemorrhoids treated with polidocanol injection combined with automatic elastic thread ligation operation (RPH).
Methods: A total of 100 patients with mixed hemorrhoids who visited our hospital from October 2022 to September 2023 were selected and randomly divided into the control group ( = 50) and the treatment group ( = 50) by rolling the dice.
Oropharyngeal Lymphogranuloma Venereum: A Clinical Reasoning Challenge and Literature Review.
J Community Hosp Intern Med Perspect
January 2025
Internal Medicine Residency Program, Florida State University College of Medicine, Tallahassee, FL, USA.
Lymphogranuloma venereum (LGV) is a sexually transmitted infection typically caused by serovars L1-L3 of . These serovars are tissue-invasive with a preponderance for lymphatic spread and can be acquired via unprotected oral, anal, or vaginal sex. We present the case of a 23-year-old with a prior history of syphilis admitted with four weeks of progressively enlarging painful right cervical lymphadenopathy.
View Article and Find Full Text PDFThe Clinical Utility of Anorectal Manometry: A Review of Current Practices.
Gastro Hep Adv
October 2024
Division of Digestive Diseases and Nutrition, Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois.
Anorectal manometry (ARM) is a diagnostic test that utilizes pressure sensors to dynamically measure intraluminal anal and rectal pressures, thus providing an objective evaluation of anorectal functional parameters (tone, contractility, and relaxation), coordination and reflex activity, and sensation. ARM is a useful test for numerous indications including for the assessment and management of functional anorectal disorders such as fecal incontinence, functional defecatory disorders, and functional anorectal pain, preoperative assessment of anorectal function, and in facilitating/assessing response to biofeedback training. In addition, while many functional anorectal disorders present with overlapping symptoms (ie constipation, anorectal pain), ARM allows delineation of more specific disease processes and may guide treatment more effectively.
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