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Microfluidic fractionation of microplastics, bacteria and microalgae with induced-charge electro-osmotic eddies.
Anal Chim Acta
February 2025
School of Control Engineering, Northeastern University at Qinhuangdao, Qinhuangdao, 066004, PR China; Hebei Key Laboratory of Micro-Nano Precision Optical Sensing and Measurement Technology, Qinhuangdao, 066004, PR China. Electronic address:
Background: Fractionation of microalgal cells has important applications in producing pharmaceuticals and treating diseases. Multiple types of microalgal cells generally coexist in the oceans or lakes and are easily contaminated by microplastics and bacteria. Therefore, it is of paramount significance to develop an effective fractionation approach for microalgal cells for biological applications.
View Article and Find Full Text PDFAliphatic substrates-mediated unique rapid room temperature synthesis of carbon quantum dots for fenofibrate versatile analysis.
Anal Chim Acta
February 2025
Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt. Electronic address:
Background: The current synthetic strategies for carbon dots (CDs) are usually time-consuming, rely on complicated processes, and need high temperatures and energy. Recent studies have successfully synthesized CDs at room temperature. Unfortunately, most CDs synthesized at room temperature are obtained under harsh reaction conditions, prepared using aromatic precursors, or need a long time to generate.
View Article and Find Full Text PDFThe latest applications of exosome-mediated drug delivery in anticancer therapies.
Colloids Surf B Biointerfaces
January 2025
School of Pharmacy, Guilin Medical University, Guilin 541199, China; Guangxi Key Laboratory of Drug Discovery and Optimization, School of Pharmacy, Guilin Medical University, Guilin 541199, China. Electronic address:
In recent years, the significant role of anticancer drugs in cancer treatment has garnered considerable attention. However, the application of these drugs is largely limited by their short half-life in blood circulation, low cellular uptake efficiency, and off-target effects. Exosomes, which serve as crucial messengers in intercellular communication, exhibit unique advantages in molecular delivery compared to traditional synthetic carriers, thereby offering new possibilities for modern drug delivery systems.
View Article and Find Full Text PDFPhyloMix: Enhancing microbiome-trait association prediction through phylogeny-mixing augmentation.
Bioinformatics
January 2025
Cheriton School of Computer Science, University of Waterloo, Waterloo, Ontario, Canada.
Article Synopsis
- Understanding the associations between traits and microbial composition is critical for microbiome research, but machine learning models often struggle due to the data's high-dimensional, compositional, and imbalanced nature.
- To tackle these challenges, a new data augmentation method called PhyloMix has been developed, which uses phylogenetic relationships to generate synthetic microbial samples that enhance model performance.
- PhyloMix significantly outperforms other data augmentation techniques and is effective in both supervised learning and contrastive representation learning, demonstrating its broad applicability in microbiome studies.
[Characteristics of immune response induced by mucosal immunization with recombinant adenovirus of Mycobacterium tuberculosis phosphodiesterase].
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
January 2025
Department of Microbiology and Pathogenic Biology, Air Force Military Medical University, Xi'an 710032, China. *Corresponding authors, E-mail:
Objective The prevalence of drug-resistant Mycobacterium tuberculosis (Mtb) strains is exacerbating the global burden of tuberculosis (TB), highlighting the urgent need for new treatment strategies for TB. Methods The recombinant adenovirus vaccine expressing cyclic di-adenosine monophosphate (c-di-AMP) phosphodiesterase B (CnpB) (rAd-CnpB), was administered to normal mice via mucosal immunization, either alone or in combination with drug therapy, to treat Mtb respiratory infections in mice.Enzyme-linked immunosorbent assay (ELISA) was used to detect the levels of antibodies in serum and bronchoalveolar lavage fluid (BALF).
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