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Non-canonical Roles of Complement in the CNS: From Synaptic Organizer to Presynaptic Modulator of Glutamate Transmission.
Curr Neuropharmacol
January 2025
Department of Pharmacy, DIFAR, Pharmacology and Toxicology Section, University of Genoa, Viale Cembrano 4, 16148, Genoa, Italy.
The central nervous system (CNS) is not an immune-privileged compartment, but it is intimately intertwined with the immune system. Among the components shared by the two compartments is the complement, a main constituent of innate immunity, which is also produced centrally and controls the development and organization of synaptic connections. Complement is considered a doubled-faced system that, besides controlling the physiological development of the central network, also subserves synaptic engulfment pivotal to the progression of neurodegenerative diseases.
View Article and Find Full Text PDFGlobal Publication Trends and Research Hotspots of Diabetes and Osteoporosis.
Endocr Metab Immune Disord Drug Targets
January 2025
Department of Rheumatology and Immunology, The First Affiliated Hospital of Army Medical University, Chongqing, China.
Background: Diabetes and osteoporosis, as chronic diseases with high incidence, have caused deep concern in the field of global public health due to their high morbidity and mortality. More importantly, the complex and close relationship between diabetes and osteoporosis has gradually become the focus of scientific research. It is very meaningful to carry out bibliometric analysis in the research field of diabetes and osteoporosis to describe the current international trend and present a visual representation of the past and emerging trends of diabetes and osteoporosis in the past decade.
View Article and Find Full Text PDFSituational assessment of physical rehabilitation services in Zambia: issues and challenges.
Disabil Rehabil
January 2025
Discipline of Public Health Medicine, School of Nursing and Public Health, University of KwaZulu-Natal, Durban, Republic of South Africa.
Purpose: The necessity to enhance physical rehabilitation services in Zambia has been recognised. To achieve this through expanding human resources for health in rehabilitation and increasing service coverage, it is essential to comprehensively understand the current issues and challenges in physical rehabilitation within the country. This paper aimed to conduct a situational assessment of physical rehabilitation services in Zambia.
View Article and Find Full Text PDFA quasi-experimental study of trigger films for teaching the doctor-patient relationship.
Indian J Med Ethics
January 2025
Director Professor, Department of Physiology, University College of Medical Sciences, Delhi University, Delhi, INDIA.
Background: It is challenging to teach the complexity of the doctor-patient relationship through attitude, ethics, and communication (AETCOM) modules, particularly without being formally trained and especially to first-year medical students who do not interact directly with patients. The present study was undertaken to assess the effectiveness of trigger films (TFs) or short movie clips as a teaching-learning tool to train undergraduate medical students on various aspects of doctor-patient relationships.
Methods: Two modules on various aspects of the doctor-patient relationship were developed using TFs and written case studies and implemented on Phase Ⅰ medical students.
Reasons for retraction of clinical research articles in PubMed indexed medical journals from 2012 to 2022.
Indian J Med Ethics
January 2025
Department of Clinical Pharmacology, Toipwala National Medical College and BYL Nair Charitable Hospital, Mumbai 400008, Maharashtra, INDIA.
Background: Misconduct in the publication of research articles is a serious concern for the scientific community. This study was conducted with the objective to assess various reasons for retraction of clinical research articles published in PubMed indexed journals from all over the world since 2012 to 2022.
Methods: A search was performed on the PubMed database for retracted research articles using filters for "retracted publication".
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