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MLH1, BRAF and p53 - searching for significant markers to predict evolution towards adenocarcinoma in colonic sessile serrated lesions.
Rom J Morphol Embryol
June 2022
Department of Pathology, Colentina University Hospital, Bucharest, Romania;
Background And Aim: Colonic serrated lesions are premalignant lesions, using an alternative malignization pathway, including multiple genetic and epigenetic alterations, as: mismatch repair deficiency due to MutL homolog 1 (MLH1) promoter methylation, tumor protein p53 (TP53) mutations, activating mutations of v-Raf murine sarcoma viral oncogene homolog B (BRAF) and Kirsten rat sarcoma viral oncogene homolog (KRAS). Our study aims to evaluate MLH1, BRAF and p53 immunohistochemical (IHC) status in sessile serrated lesions (SSLs), with and without dysplasia.
Materials And Methods: This is a retrospective case-control study including 20 SSLs with dysplasia and 20 SSLs without dysplasia (matching sex and age).
Florid reactive lymphoid hyperplasia of the lower female genital tract (lymphoma-like lesion): a benign condition that frequently harbors clonal immunoglobulin heavy chain gene rearrangements.
Am J Surg Pathol
February 2010
Department of Pathology, Massachusetts General Hospital, Brigham and Women's Hospital, Boston, MA, USA.
Lymphoma-like lesions (LLL) of the lower female genital tract are florid reactive inflammatory processes that mainly occur in women in their reproductive years. Histologically, they are characterized by a dense lymphoid infiltrate with admixed large cells that is often suspicious for lymphoma. In contrast to lymphoma, however, they are superficial lesions that typically show surface erosion and a mixed lymphoid infiltrate and do not have evidence of a mass, deep invasion, or prominent sclerosis.
View Article and Find Full Text PDFPyogenic granuloma clinically and dermoscopically mimicking pigmented melanoma.
Dermatol Online J
October 2009
Dermatology Department, Hospital de Sant Pau i Santa Tecla, Tarragona, Spain.
Pyogenic granuloma is a common, benign, acquired, vascular growth of skin and mucous membranes that usually presents as a solitary, rapidly, growing, papule or polyp that bleeds easily after minor trauma. The clinical diagnosis of this lesion is usually straightforward. Moreover, the dermoscopic features associated with pyogenic granulomas have been described recently.
View Article and Find Full Text PDFA case of nasal polyposis with stroma cell atypia in a 33-year-old man is reported. The light microscopic appearance made a rhabdomyosarcoma strongly suspected because of the presence of polymorphous, acidophilic, rhabdomyoblast-like cells. The clinical course was that of an ordinary recurring inflammatory nasal polyp.
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