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Effect of the cholinergic system of the lateral periaqueductal gray (lPAG) on blood pressure and heart rate in normal and hydralazine hypotensive rats.
Iran J Basic Med Sci
January 2023
Division of Neurocognitive Sciences, Psychiatry, and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Objectives: Due to the presence of the cholinergic system in the lateral periaqueductal gray (lPAG) column, the cardiovascular effects of acetylcholine (ACH) and its receptors in normotensive and hydralazine (HYD) hypotensive rats in this area were evaluated.
Materials And Methods: After anesthesia, the femoral artery was cannulated and systolic blood pressure (SBP), mean arterial pressure (MAP), heart rate (HR), and also electrocardiogram for evaluation of low frequency (LF) and high frequency (HF) bands, important components of heart rate variability (HRV), were recorded. ACH, atropine (Atr, a muscarinic antagonist), and hexamethonium (Hex, an antagonist nicotinic) alone and together microinjected into lPAG, changes (Δ) of cardiovascular responses and normalized (n) LF, HF, and LF/HF ratio were analyzed.
Exercise training causes skeletal muscle venular growth and alters hemodynamic responses in spontaneously hypertensive rats.
J Hypertens
May 2001
Department of Physiology and Biophysics, ICB, University of São Paulo, Brazil.
Objective: To investigate whether training changes skeletal muscle venular profile and hemodynamic responses to exercise we studied spontanesouly hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats submitted to training programme (T = 50-60% of VO2max).
Design: Training (T) was performed on a treadmill over a period of 13 weeks. Age-matched control groups were kept sedentary (S).
Effects of alpha 1- and alpha 2-adrenoceptor antagonists on venous tone in conscious rats.
Eur J Pharmacol
July 1990
Department of Pharmacology and Therapeutics, Faculty of Medicine, University of British Columbia, Vancouver, Canada.
The dose-response effects of hexamethonium, prazosin and rauwolscine - a ganglionic blocker, alpha 1- and alpha 2-adrenoceptor antagonists, respectively - on mean arterial pressure (MAP) and mean circulatory filling pressure (MCFP), an index of body venous tone, were examined in conscious and unrestrained rats. Prazosin and rauwolscine were also administered to rats after venous tone was elevated by drug-induced hypotension via the infusion of the vasodilator drug hydralazine. The effects of these drugs were compared with those of the vehicle, acidified glucose solution, administered to control rats.
View Article and Find Full Text PDFEffects of calcium channel blockers and hydralazine on plasma glucose levels in streptozotocin-induced diabetic rats in vivo.
Jpn J Pharmacol
March 1990
Group of Biochemical Pharmacology, Faculty of Pharmaceutical Sciences, Josai University, Saitama, Japan.
Effects of calcium channel blockers from structurally different classes and hydralazine on plasma glucose levels were examined in streptozotocin-induced diabetic rats in vivo. Non-dihydropyridine calcium channel blockers (verapamil, diltiazem, 1.0-10 mg/kg, i.
View Article and Find Full Text PDFAtrial natriuretic factor-induced systemic vasoconstriction in conscious dogs, rats, and monkeys.
Circ Res
March 1990
Department of Medicine, Harvard Medical School, Brigham and Women's and Massachusetts General Hospital, Boston.
This study addresses the hypothesis that atrial natriuretic factor (ANF) is a primary vasodilator, which reduces arterial pressure directly and increases total peripheral resistance secondarily by reflex mechanisms. The effects of 30-minute infusions of ANF (0.3 micrograms/kg/min i.
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