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Cisatracurium pharmacokinetics and pharmacodynamics during hypothermic cardiopulmonary bypass in infants and children.
Paediatr Anaesth
March 2011
Department of Anesthesia, McGill University, Montreal Children's Hospital, Montreal, QC, Canada.
Background: Hypothermia potentiates neuromuscular blockade in adults during cardiopulmonary bypass (CPB) but the pediatric literature is sparse. Temperature-dependent Hoffman degradation of cisatracurium may allow reduction in infusion rate (IR) during hypothermia. The effect of hypothermic CPB on the pharmacokinetics (PK) and pharmacodynamics (PD) of cisatracurium has not been described in children.
View Article and Find Full Text PDFCisatracurium in different doses versus atracurium during general anesthesia for abdominal surgery.
Saudi J Anaesth
September 2010
Department of Anaesthesia, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.
Background: Cisatracurium in clinical practice is devoid of histamine-induced cardiovascular effects. On the other hand, 2 ED(95) doses of cisatracurium (100 µ g/kg) do not create satisfactory intubating conditions such as those seen with equipotent doses of atracurium. The recommended intubating dose of cisatracurium is 3 ED(95).
View Article and Find Full Text PDF[Anesthesia for a patient with mitochondrial respiratory chain complex III deficiency].
Rev Esp Anestesiol Reanim
November 2006
Servicio de Anestesiología y Reanimación, Hospital Garcia Orcoyen, C/ Santa Soria, 22, 31200 Estella, Navarra.
Mitochondrial myopathies make up a group of rare disorders whose onset is in childhood or adolescence. Muscle and central nervous system involvement is variable. Mitochondrial respiratory chain complex III deficiency (coenzyme Q - cytochrome C reductase) can manifest as exercise intolerance, myopathy, encephalopathy, and myocardial disease.
View Article and Find Full Text PDFErythemas caused by electrodes while monitoring neuromuscular blockade: three cases.
J Anesth
September 2005
Department of Anesthesia, Kyoto City Hospital, 1-2 Mibu-Higashitakadacho, Nakagyo-ku, Kyoto 604-8845, Japan.
Skin erythemas formed in three patients during surgery at the sites where negative electrodes had been attached to stimulate the ulnar nerve for a neuromuscular transmission monitor (Relaxograph). The patients were all women, aged 52, 62, and 74 years, and general anesthesia lasted 8 h 20 min, 4 h 50 min, and 8 h 45 min, respectively. The electrodes used were disposable ECG electrodes in the first two patients and one designed for a neuromuscular monitor in the third; all were carbon-coated and then covered with gel.
View Article and Find Full Text PDFHierarchical rule-based monitoring and fuzzy logic control for neuromuscular block.
J Clin Monit Comput
February 2003
Department of Mechanical Engineering, Yuan Ze University, Chung-Li, Taoyuan, Taiwan.
Objective: The important task for anaesthetists is to provide an adequate degree of neuromuscular block during surgical operations, so that it should not be difficult to antagonize at the end of surgery. Therefore, this study examined the application of a simple technique (i.e.
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